Membrane Proteins: The Key Players of a Cancer Cell

被引：85

作者：

Kampen, Kim R. ^{[1
]}

机构：

[1] Univ Groningen, Div Pediat Oncol Hematol, Dept Pediat, Beatrix Childrens Hosp,Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands

来源：

JOURNAL OF MEMBRANE BIOLOGY | 2011年 / 242卷 / 02期

关键词：

Cancer therapy; Gene expression profiling; Membrane proteins; Nanocarriers; Receptor tyrosine kinases; Surgery; BREAST-CANCER; PROGNOSTIC-SIGNIFICANCE; GENE-EXPRESSION; GROWTH; TRASTUZUMAB; CD59; OVEREXPRESSION; NANOCARRIERS; DOXORUBICIN; INHIBITION;

D O I：

10.1007/s00232-011-9381-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane proteins are involved in the prognosis of the most common forms of cancer. Membrane proteins are the hallmark of a cancer cell. The overexpressed membrane receptors are becoming increasingly important in cancer cell therapy. Current renewing therapy approaches based on receptor overexpression include; antibody therapy, nanocarrier drug delivery, and fluorescent tumor imaging in surgery. Gene profiling reveals cancer specific signatures and may identify membrane proteins that are related to cancer progression and lead to the development of improved therapy strategies in the future.

引用

页码：69 / 74

页数：6

共 45 条

[31] Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer [J].

Schlomm, Thorsten ;

Kirstein, Patrick ;

Lwers, Liv ;

Daniel, Birte ;

Steuber, Thomas ;

Walz, Jochen ;

Chun, Felix H. K. ;

Haese, Alexander ;

Kollermann, Jens ;

Graefen, Markus ;

Huland, Hartwig ;

Sauter, Guido ;

Simon, Ronald ;

Erbersdobler, Andreas .

CLINICAL CANCER RESEARCH, 2007, 13 (22) :6579-6584

[32] PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer [J].

Serra, V. ;

Scaltriti, M. ;

Prudkin, L. ;

Eichhorn, P. J. A. ;

Ibrahim, Y. H. ;

Chandarlapaty, S. ;

Markman, B. ;

Rodriguez, O. ;

Guzman, M. ;

Rodriguez, S. ;

Gili, M. ;

Russillo, M. ;

Parra, J. L. ;

Singh, S. ;

Arribas, J. ;

Rosen, N. ;

Baselga, J. .

ONCOGENE, 2011, 30 (22) :2547-2557

[33] (-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells [J].

Shimizu, Masahito ;

Shirakami, Yohei ;

Sakai, Hiroyasu ;

Yasuda, Yoichi ;

Kubota, Masaya ;

Adachi, Seiji ;

Tsurumi, Hisashi ;

Hara, Yukihiko ;

Moriwaki, Hisataka .

CHEMICO-BIOLOGICAL INTERACTIONS, 2010, 185 (03) :247-252

[34] Preclinical radioimmunotargeting of folate receptor alpha using the monoclonal antibody conjugate DOTA-MORAb-003 [J].

Smith-Jones, Peter M. ;

Pandit-Taskar, Neeta ;

Cao, Wei ;

O'Donoghue, Joseph ;

Philips, Martin D. ;

Carrasquillo, Jorge ;

Konner, Jason A. ;

Old, Lloyd J. ;

Larson, Steven M. .

NUCLEAR MEDICINE AND BIOLOGY, 2008, 35 (03) :343-351

[35] Opportunities and obstacles to combination targeted therapy in renal cell cancer [J].

Sosman, Jeffrey A. ;

Puzanov, Igor ;

Atkins, Michael B. .

CLINICAL CANCER RESEARCH, 2007, 13 (02) :764S-769S

[36] Phase I Pharmacologic and Biologic Study of Ramucirumab (IMC-1121B), a Fully Human Immunoglobulin G1 Monoclonal Antibody Targeting the Vascular Endothelial Growth Factor Receptor-2 [J].

Spratlin, Jennifer L. ;

Cohen, Roger B. ;

Eadens, Matthew ;

Gore, Lia ;

Camidge, D. Ross ;

Diab, Sami ;

Leong, Stephen ;

O'Bryant, Cindy ;

Chow, Laura Q. M. ;

Serkova, Natalie J. ;

Meropol, Neal J. ;

Lewis, Nancy L. ;

Chiorean, E. Gabriela ;

Fox, Floyd ;

Youssoufian, Hagop ;

Rowinsky, Eric K. ;

Eckhardt, S. Gail .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (05) :780-787

[37] Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging [J].

Steelman, Linda S. ;

Chappell, William H. ;

Abrams, Stephen L. ;

Kempf, C. Ruth ;

Long, Jacquelyn ;

Laidler, Piotr ;

Mijatovic, Sanja ;

Maksimovic-Ivanic, Danijela ;

Stivala, Franca ;

Mazzarino, Maria C. ;

Donia, Marco ;

Fagone, Paolo ;

Malaponte, Graziella ;

Nicoletti, Ferdinando ;

Libra, Massimo ;

Milella, Michele ;

Tafuri, Agostino ;

Bonati, Antonio ;

Baesecke, Joerg ;

Cocco, Lucio ;

Evangelisti, Camilla ;

Martelli, Alberto M. ;

Montalto, Giuseppe ;

Cervello, Melchiorre ;

McCubrey, James A. .

AGING-US, 2011, 3 (03) :192-222

[38] Enhancing Surgical Vision by Using Real-Time Imaging of αvβ3-Integrin Targeted Near-Infrared Fluorescent Agent [J].

Themelis, George ;

Harlaar, Niels J. ;

Kelder, Wendy ;

Bart, Joost ;

Sarantopoulos, Athanasios ;

van Dam, Gooitzen M. ;

Ntziachristos, Vasilis .

ANNALS OF SURGICAL ONCOLOGY, 2011, 18 (12) :3506-3513

[39] PROGNOSTIC-SIGNIFICANCE OF HER-2 ONCOPROTEIN EXPRESSION IN BREAST-CANCER - A 30-YEAR FOLLOW-UP [J].

TOIKKANEN, S ;

HELIN, H ;

ISOLA, J ;

JOENSUU, H .

JOURNAL OF CLINICAL ONCOLOGY, 1992, 10 (07) :1044-1048

[40] Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials [J].

Viani, Gustavo A. ;

Afonso, Sergio L. ;

Stefano, Eduardo J. ;

De Fendi, Ligia I. ;

Soares, Francisco V. .

BMC CANCER, 2007, 7 (1)

← 1 2 3 4 5 →