Membrane Proteins: The Key Players of a Cancer Cell

被引：85

作者：

Kampen, Kim R. ^{[1
]}

机构：

[1] Univ Groningen, Div Pediat Oncol Hematol, Dept Pediat, Beatrix Childrens Hosp,Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands

来源：

JOURNAL OF MEMBRANE BIOLOGY | 2011年 / 242卷 / 02期

关键词：

Cancer therapy; Gene expression profiling; Membrane proteins; Nanocarriers; Receptor tyrosine kinases; Surgery; BREAST-CANCER; PROGNOSTIC-SIGNIFICANCE; GENE-EXPRESSION; GROWTH; TRASTUZUMAB; CD59; OVEREXPRESSION; NANOCARRIERS; DOXORUBICIN; INHIBITION;

D O I：

10.1007/s00232-011-9381-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane proteins are involved in the prognosis of the most common forms of cancer. Membrane proteins are the hallmark of a cancer cell. The overexpressed membrane receptors are becoming increasingly important in cancer cell therapy. Current renewing therapy approaches based on receptor overexpression include; antibody therapy, nanocarrier drug delivery, and fluorescent tumor imaging in surgery. Gene profiling reveals cancer specific signatures and may identify membrane proteins that are related to cancer progression and lead to the development of improved therapy strategies in the future.

引用

页码：69 / 74

页数：6

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