Efficacy and safety of vinorelbine plus cisplatin chemotherapy for patients with recurrent and/or metastatic salivary gland cancer of the head and neck

被引：28
作者：
Hong, Min Hee [1 ]
Kim, Chang Gon [1 ,5 ]
Koh, Yoon Woo [2 ]
Choi, Eun Chang [2 ]
Kim, Jinna [3 ]
Yoon, Sun Och [4 ]
Kim, Hye Ryun [1 ]
Cho, Byoung Chul [1 ]
机构：
[1] Yonsei Univ, Div Med Oncol, Dept Internal Med, Yonsei Canc Ctr,Coll Med, 50 Yonsei Ro, Seoul 120752, South Korea
[2] Yonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul, South Korea
[3] Yonsei Univ, Dept Radiol, Coll Med, Seoul, South Korea
[4] Yonsei Univ, Dept Pathol, Coll Med, Seoul, South Korea
[5] Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2018年 / 40卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
cisplatin; efficacy; safety; salivary gland cancer; vinorelbine; ADENOID CYSTIC CARCINOMA; PHASE-II TRIAL; SYSTEMIC THERAPY; DUCT CARCINOMA; COMBINATION CHEMOTHERAPY; DISTANT METASTASES; MALIGNANT-TUMORS; CYCLOPHOSPHAMIDE; MANAGEMENT; TRASTUZUMAB;
D O I：
10.1002/hed.24933
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
BackgroundThe purpose of this study was to investigate the efficacy and safety of vinorelbine plus cisplatin chemotherapy in patients with recurrent and/or metastatic salivary gland cancer of the head and neck. MethodsIn this single-arm phase II study, patients with recurrent and/or metastatic salivary gland cancer were treated with i.v. vinorelbine (25 mg/m(2)) on days 1 and 8 plus cisplatin (80 mg/m(2)) on day 1 every 3 weeks for 4 or 6 cycles. The primary endpoint was the objective response rate. Progression-free survival (PFS), overall survival (OS), and adverse events were also assessed. ResultsBetween September 2008 and November 2014, 40 patients with recurrent and/or metastatic salivary gland cancer received vinorelbine plus cisplatin chemotherapy. The objective response rate was 35.0%, including 1 complete response. Median PFS and OS rates were 6.3 months and 16.9 months, respectively. No treatment-related deaths occurred. ConclusionAdministering vinorelbine plus cisplatin chemotherapy to patients with recurrent and/or metastatic salivary gland cancers is safe and effective.
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收藏
页码：55 / 62
页数：8
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