New Antiproliferative Polyunsaturated Epoxy-Heneicosane Derivatives Isolated from the Brown Alga Lobophora variegata

被引：5
作者：
Avila, Fabio N. [1 ]
Pinto, Francisco C. L. [1 ]
Carneiro, Pedro B. M. [2 ]
Ferreira, Kayanny Q. [3 ]
Wilke, Diego, V [3 ]
Nogueira, Nddia A. P. [4 ]
Silveira, Edilberto R. [1 ]
Pessoa, Otilia Deusdenia L. [1 ]
机构：
[1] Univ Fed Ceara, Dept Quim Organ & Inorgan, BR-60021970 Fortaleza, Ceara, Brazil
[2] Univ Fed Piaui, Campus Minist Reis Velloso, BR-64202020 Parnaiba, PI, Brazil
[3] Univ Fed Ceara, Dept Fisiol & Farmacol, BR-60430275 Fortaleza, Ceara, Brazil
[4] Univ Fed Ceara, Dept Anal Clin & Toxicol, BR-60430370 Fortaleza, Ceara, Brazil
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2019年 / 30卷 / 02期
关键词：
Lobophora variegata; brown algae; 3,4-epoxy lobophorenes; antiproliferative activity; CANCER CELL APOPTOSIS; PHAEOPHYCEAE; DICTYOTALES; PHEROMONE; ASSAY; ACID;
D O I：
10.21577/0103-5053.20180190
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two new polyunsaturated 3,4-epoxy-heneicosane derivatives named as epoxy-lobophorene A and epoxy-lobophorene B were isolated from the brown alga Lobophora variegata, in addition to nine known compounds. The structures of the new compounds were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). The isolated compounds were submitted to antiproliferative assays against the human colon cancer cell line HCT-116, human metastatic prostate cancer PC-3M, murine metastatic melanoma B16-F10 and murine fibroblast cell line L929 and also tested as antibacterial. Both 3,4-epoxy lobophorene A and 3,4-epoxy lobophorene B depicted moderate antiproliferative effect against cell lines. None of them showed antibacterial activity.
引用
收藏
页码：406 / 412
页数：7
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