Characterization of Collagen/Beta Glucan Hydrogels Crosslinked with Tannic Acid

被引:13
|
作者
Michalska-Sionkowska, Marta [1 ]
Warzynska, Oliwia [1 ]
Kaczmarek-Szczepanska, Beata [2 ]
Lukowicz, Krzysztof [3 ]
Osyczka, Anna Maria [3 ]
Walczak, Maciej [1 ]
机构
[1] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Dept Environm Microbiol & Biotechnol, PL-87100 Torun, Poland
[2] Nicolaus Copernicus Univ Torun, Fac Chem, Dept Biomaterials & Cosmet Chem, PL-87100 Torun, Poland
[3] Jagiellonian Univ, Fac Biol, Inst Zool & Biomed Res, Dept Biol & Cell Imaging, PL-31007 Krakow, Poland
关键词
hydrogel; tannic acid; antimicrobial properties; collagen; beta-glucan; biopolymers; HaCaT cells; MECHANICAL-PROPERTIES; LINKING; ANTIOXIDANT;
D O I
10.3390/polym13193412
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Hydrogels based on collagen/beta-glucan crosslinked with tannic acid were obtained by neutralization using dialysis. The presence of tannic acid allowed obtaining stable hydrogel materials with better mechanical properties. Tannic acid was released from matrices gradually and not rapidly. The antioxidant properties of the obtained hydrogels increased over the course of their incubation in culture media and were dependent on the concentration of tannic acid in the matrices. The obtained materials influenced dehydrogenase activity and the ATP level of pathogens. Additionally, the materials' extracts improved the HaCaT cells' viability. Therefore, the obtained hydrogels seem to be promising biocompatible materials which display antimicrobial properties.
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页数:14
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