Bonus-freeze: benefit or risk? Two-year outcome and procedural comparison of a "bonus-freeze" and "no bonus-freeze" protocol using the second-generation cryoballoon for pulmonary vein isolation

被引：56

作者：

Heeger, Christian-H. ^{[1
]}

Wissner, Erik ^{[1
]}

Wohlmuth, Peter ^{[1
]}

Mathew, Shibu ^{[1
]}

Hayashi, Kentaro ^{[1
]}

Sohns, Christian ^{[1
]}

Reissmann, Bruno ^{[1
]}

Lemes, Christine ^{[1
]}

Maurer, Tilman ^{[1
]}

Saguner, Ardan M. ^{[1
]}

Santoro, Francesco ^{[1
]}

Riedl, Johannes ^{[1
]}

Ouyang, Feifan ^{[1
]}

Kuck, Karl-Heinz ^{[1
]}

Metzner, Andreas ^{[1
]}

机构：

[1] Asklepios Klin St Georg, Dept Cardiol, Lohmuhlenstr 5, D-20099 Hamburg, Germany

来源：

CLINICAL RESEARCH IN CARDIOLOGY | 2016年 / 105卷 / 09期

关键词：

Atrial fibrillation; Pulmonary vein isolation; Cryoballoon; Long-term follow-up; PHRENIC-NERVE PALSY; 28 MM CRYOBALLOON; ATRIAL-FIBRILLATION; 28-MM CRYOBALLOON; FOLLOW-UP; ABLATION; PREVENTION; LESIONS;

D O I：

10.1007/s00392-016-0987-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Second-generation cryoballoon based pulmonary vein isolation has demonstrated encouraging acute and mid-term clinical outcome. Customarily, a bonus-freeze is applied after successful pulmonary vein isolation. To compare the long-term clinical outcome and safety profile of a bonus-freeze and a no bonus-freeze protocol. A total of 120 consecutive patients with paroxysmal [95/120 (79 %)] or persistent atrial fibrillation [25/120 (21 %)] underwent CB2-based PVI. Freeze-cycle duration was 240 s. In the first 60 patients a bonus-freeze was applied after successful PVI (group 1), while in the following 60 patients the bonus-freeze was omitted (group 2). Procedure and fluoroscopy times were significantly shorter in group 2 [113.8 +/- 32 vs 138.2 +/- 29 min (p = 0.03) and 19.2 +/- 6 vs 24.3 +/- 8 min (p = 0.02)]. No differences in procedural complications were found. During a mean follow-up of 849 +/- 74 (group 1) and 848 +/- 101 days (group 2, p = 0.13) 69 % of patients (group 1) and 67 % of patients (group 2) remained in stable sinus rhythm without any differences between the groups (p = 0.69). Freedom from atrial fibrillation after second-generation cryoballoon based pulmonary vein isolation and a follow-up of > 2 years is comparable when applying a bonus- and a no bonus-freeze protocol, while procedure and fluoroscopy times are significantly shorter when omitting the bonus-freeze. No differences in periprocedural complications were identified.

引用

页码：774 / 782

页数：9

共 22 条

[21]

Tebbenjohanns J, 2015, EUROPACE

[22] One-year clinical success of a 'no-bonus' freeze protocol using the second-generation 28 mm cryoballoon for pulmonary vein isolation [J].

Wissner, Erik ;

Heeger, Christian-Hendrik ;

Grahn, Hanno ;

Reissmann, Bruno ;

Wohlmuth, Peter ;

Lemes, Christine ;

Rausch, Peter ;

Mathew, Shibu ;

Rillig, Andreas ;

Deiss, Sebastian ;

Maurer, Tillman ;

Lin, Tina ;

Tilz, Roland Richard ;

Ouyang, Feifan ;

Kuck, Karl-Heinz ;

Metzner, Andreas .

EUROPACE, 2015, 17 (08) :1236-1240

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