Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for In Vivo Cancer Treatment

被引：307

作者：

Chen, Hongmin ^{[1
,2
,3
,4
]}

Wang, Geoffrey D. ^{[1
]}

Chuang, Yen-Jun ^{[5
]}

Zhen, Zipeng ^{[1
,2
]}

Chen, Xiaoyuan ^{[6
]}

Biddinger, Paul ^{[7
]}

Hao, Zhonglin ^{[8
]}

Liu, Feng ^{[5
]}

Shen, Baozhong ^{[3
,4
]}

Pan, Zhengwei ^{[5
]}

Xie, Jin ^{[1
,2
]}

机构：

[1] Univ Georgia, Dept Chem, Athens, GA 30602 USA

[2] Univ Georgia, Bioimaging Res Ctr, Athens, GA 30602 USA

[3] Harbin Med Univ, Hosp 4, Dept Radiol, Harbin 157, Peoples R China

[4] Harbin Med Univ, Mol Imaging Res Ctr, Harbin 157, Peoples R China

[5] Univ Georgia, Coll Engn, Athens, GA 30602 USA

[6] Natl Inst Biomed Imaging & Bioengn, NIH, Rockville, MD 20852 USA

[7] Georgia Regents Univ, Dept Pathol, Augusta, GA 30912 USA

[8] Georgia Regents Univ, Dept Internal Med, Med Coll Georgia, Augusta, GA 30912 USA

来源：

NANO LETTERS | 2015年 / 15卷 / 04期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

nanomedicine; X-PDT; nanoscintillator; radioluminescence nanophosphors; singlet oxygen; cancer treatment; UP-CONVERSION NANOPARTICLES; RETICULOENDOTHELIAL SYSTEM CLEARANCE; MESOPOROUS SILICA; LIGHT; LUMINESCENCE; IRRADIATION; ALUMINATE; RADIATION; BIOLOGY; EU2+;

D O I：

10.1021/nl504044p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photodynamic therapy is a promising :treatment method, but its applications are limited by the shallow penetration of visible light Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach That allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a Core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.

引用

页码：2249 / 2256

页数：8

共 47 条

[1] Photodynamic Therapy of Cancer: An Update
Agostinis, Patrizia
Berg, Kristian
Cengel, Keith A.
Foster, Thomas H.
Girotti, Albert W.
Gollnick, Sandra O.
Hahn, Stephen M.
Hamblin, Michael R.
Juzeniene, Asta
Kessel, David
Korbelik, Mladen
Moan, Johan
Mroz, Pawel
Nowis, Dominika
Piette, Jacques
Wilson, Brian C.
Golab, Jakub
[J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2011, 61 (04) : 250 - 281
[2] Light-sensitive Intelligent Drug Delivery Systems
Alvarez-Lorenzo, Carmen
Bromberg, Lev
Concheiro, Angel
[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2009, 85 (04) : 848 - 860
[3] Shedding light on the dynamics of endocytosis and viral budding
Bao, G
Bao, XR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (29) : 9997 - 9998
[4] Limited-angle x-ray luminescence tomography: methodology and feasibility study
Carpenter, C. M.
Pratx, G.
Sun, C.
Xing, L.
[J]. PHYSICS IN MEDICINE AND BIOLOGY, 2011, 56 (12) : 3487 - 3502
[5] Chandler D. L., 2011, MIT NEWS 0328
[6] Nanoparticles for improving cancer diagnosis
Chen, Hongmin
Zhen, Zipeng
Todd, Trever
Chu, Paul K.
Xie, Jin
[J]. MATERIALS SCIENCE & ENGINEERING R-REPORTS, 2013, 74 (03) : 35 - 69
[7] Advances in functional X-ray imaging techniques and contrast agents
Chen, Hongyu
Rogalski, Melissa M.
Anker, Jeffrey N.
[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2012, 14 (39) : 13469 - 13486
[8] Using nanoparticles to enable simultaneous radiation and photodynamic therapies for cancer treatment
Chen, W
Zhang, J
[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2006, 6 (04) : 1159 - 1166
[9] Novel Necklace-like MAl2O4:Eu2+, Dy3+ (M = Sr, Ba, Ca) Phosphors via a CTAB-Assisted Solution-Phase Synthesis and Postannealing Approach
Chen, Xiang Ying
Ma, Chao
Li, Xiao Xuan
Shi, Cheng Wu
Li, Xue Liang
Lu, Dao Rong
[J]. JOURNAL OF PHYSICAL CHEMISTRY C, 2009, 113 (07) : 2685 - 2689
[10] Energy of the first 4f7→4f65d transition of Eu2+ in inorganic compounds
Dorenbos, P
[J]. JOURNAL OF LUMINESCENCE, 2003, 104 (04) : 239 - 260

← 1 2 3 4 5 →