Tailoring cellular metabolism in lactic acid bacteria through metabolic engineering

被引：29

作者：

Sharma, Anshula ^{[1
]}

Gupta, Gaganjot ^{[1
]}

Ahmad, Tawseef ^{[1
]}

Kaur, Baljinder ^{[1
]}

Hakeem, Khalid Rehman ^{[2
,3
]}

机构：

[1] Punjabi Univ, Dept Biotechnol, Patiala 147002, Punjab, India

[2] King Abdulaziz Univ, Fac Sci, Dept Biol Sci, Jeddah 21589, Saudi Arabia

[3] King Abdulaziz Univ, Princess Dr Najla Bint Al Saud Saud Ctr Excellenc, Jeddah, Saudi Arabia

来源：

JOURNAL OF MICROBIOLOGICAL METHODS | 2020年 / 170卷

关键词：

Central carbon metabolism; Heterologous gene expression; Synthetic metabolic engineering; Systems biology; Biosynthetic pathways; Metabolite production; PEDIOCOCCUS-ACIDILACTICI BD16; HIGH-YIELD PRODUCTION; LACTOCOCCUS-LACTIS; LACTATE-DEHYDROGENASE; EXOPOLYSACCHARIDE PRODUCTION; LACTOBACILLUS-PLANTARUM; MANNITOL PRODUCTION; STARTER CULTURES; INSERTIONAL INACTIVATION; BIOCOMPATIBLE CHEMISTRY;

D O I：

10.1016/j.mimet.2020.105862

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic engineering combines approaches of synthetic and systems biology for tailoring the existing and creating novel biosynthetic metabolic pathways in the desired industrial microorganisms for production of biofuels, bio-materials and environmental applications. Lactic acid bacteria (LAB) are gaining attention worldwide due to their extensive utilization in food, fermentation and pharmaceutical industries owing to their GRAS status. Well-elucidated genetics and regulatory control of central metabolism make them potential candidates for the production of industrially valuable metabolites. With the recent advancements in metabolic engineering strategies, genetic manipulation and tailoring of cellular metabolism is being successfully carried out in various LAB strains as they are providing highly efficient and industrially competitive robust expression systems. Thus, this review presents a concise overview of metabolic engineering strategies available for the comprehensive tailoring of lactic acid bacterial strains for large-scale production of industrially important metabolites.

引用

页数：14

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