New Polyketides from the Marine-Derived Fungus Letendraea Sp. 5XNZ4-2

被引：6

作者：

Xu, Yan ^{[1
]}

Huang, Ruibao ^{[1
]}

Liu, Hongwei ^{[2
]}

Yan, Tingting ^{[1
]}

Ding, Wanjing ^{[1
]}

Jiang, Yongjun ^{[1
]}

Wang, Pinmei ^{[1
]}

Zheng, Daoqiong ^{[1
]}

Xu, Jinzhong ^{[1
]}

机构：

[1] Zhejiang Univ, Ocean Coll, Zhoushan Campus, Zhoushan 316021, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China

来源：

MARINE DRUGS | 2020年 / 18卷 / 01期

关键词：

marine-derived fungus; Letendraea sp; polyketide; phomopsiketone; letendronol; ABSOLUTE-CONFIGURATION; ASSIGNMENT; NMR;

D O I：

10.3390/md18010018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Marine-derived fungi have been reported to have great potential to produce structurally unique metabolites. Our investigation on secondary metabolites from marine-derived fungi resulted in the isolation of seven new polyketides (phomopsiketones D G (1-4) and letendronols A-C (5-7)) as well as one known xylarinol (8) in the cultural broth of Letendraea sp. Their structures and absolute configurations were elucidated using a set of spectroscopic and chemical methods, including HRESIMS, NMR, single-crystal X-ray diffraction, ECD calculation, and a modified version of Mosher 's method. Compound 2 showed weak inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with an IC50 value of 86 mu M.

引用

页数：15

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