Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams

被引：11

作者：

Canterbury, Daniel P. ^{[1
]}

Hesp, Kevin D. ^{[1
]}

Polivkova, Jana ^{[1
]}

机构：

[1] Pfizer Worldwide Med Chem, Eastern Point Rd, Groton, CT 06340 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 32期

关键词：

MILD CONDITIONS; ARYL CHLORIDES; HECK REACTION; COUPLING REACTIONS; LACTAMS; ACID; ARYLATION; ALKENES; OLEFINS; SCOPE;

D O I：

10.1039/c6ob01126h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the palladium-catalyzed arylation of alpha,beta-unsaturated valerolactams is reported. This new protocol provides arylation products in yields up to 95% and is applicable to a wide array of aryl and heteroaryl bromides. The optimization, scope and limitations are described.

引用

页码：7731 / 7734

页数：4

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