In Vitro Effect of Knotolan, a New Lignan from Abies sibirica, on the Growth of Hormone-Dependent Breast Cancer Cells

被引：8

作者：

Zhukova, O. S. ^{[1
]}

Fetisova, L. V. ^{[1
]}

Trishin, A. V. ^{[1
]}

Anisimova, N. Yu. ^{[1
]}

Shcherbakov, A. E. ^{[1
]}

Yashunskii, D. V. ^{[2
]}

Tsvetkov, D. E. ^{[2
]}

Men'shov, V. M. ^{[2
]}

Kiselevskii, M. V. ^{[1
]}

Nifant'ev, N. E. ^{[2
]}

机构：

[1] Russian Acad Med Sci, NN Blokhin Canc Res Ctr, Moscow, Russia

[2] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 149卷 / 04期

关键词：

lignans; phytoestrogens; breast cancer; Knotolan; POSTMENOPAUSAL WOMEN; ESTROGEN; PHYTOESTROGENS;

D O I：

10.1007/s10517-010-0981-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Here we present antiestrogenic effects of Knotolan (R), a new dietary lignan from Abies sibirica raw material. Knotolan abolished growth-stimulating effects of 17 beta-estragiol on hormone-dependent MCF-7 cells.

引用

页码：511 / 514

页数：4

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