A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers

被引：32

作者：

Mathias, Patricia I. ^{[1
]}

Connor, Thomas H. ^{[1
]}

B'Hymer, Clayton ^{[1
]}

机构：

[1] NIOSH, US Dept HHS, Ctr Dis Control & Prevent,Robert A Taft Labs, Div Appl Res & Technol,Biomonitoring & Hlth Asses, 1150 Tusculum Ave, Cincinnati, OH 45226 USA

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2017年 / 1060卷

关键词：

Liquid chromatography mass spectrometry; Urinary biomarker; Anticancer drugs; Antineoplastic drug; Occupational biomonitoring; SOLID-PHASE EXTRACTION; FLUORO-BETA-ALANINE; ANTINEOPLASTIC DRUGS; OCCUPATIONAL-EXPOSURE; SURFACE CONTAMINATION; LC-MS/MS; ENVIRONMENTAL CONTAMINATION; HOSPITAL PHARMACIES; TRACE DETERMINATION; CANADIAN HOSPITALS;

D O I：

10.1016/j.jchromb.2017.06.028

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This review describes published high performance liquid chromatography/mass spectrometry (HPLC MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC MS methods are presented, as well as future trends and limitations in this area of research.

引用

页码：316 / 324

页数：9

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