Centrosome dynamics as a source of chromosomal instability

被引：67
作者：
Nam, Hyun-Ja [1 ]
Naylor, Ryan M. [2 ]
van Deursen, Jan M. [1 ,2 ]
机构：
[1] Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN USA
来源：
TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 02期
基金：
美国国家卫生研究院;
关键词：
centrosome disjunction; centrosome movement; centrosome dynamics; chromosomal instability; cancer; AURORA-A; CENTRIOLE DUPLICATION; SPINDLE ORIENTATION; PROTEIN-KINASE; PLK1; CONTROLS; BETA-CATENIN; POLO KINASE; CYCLIN B2; SEPARATION; PHOSPHORYLATION;
D O I：
10.1016/j.tcb.2014.10.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Accurate segregation of duplicated chromosomes between two daughter cells depends on bipolar spindle formation, a. metaphase state in which sister kinetochores are attached to microtubules emanating from opposite spindle poles. To ensure bi-orientation, cells possess surveillance systems that safeguard against microtubule-kinetochore attachment defects, including the spindle assembly checkpoint and the error correction machinery. However, recent developments have identified centrosome dynamics - that is, centrosome disjunction and poleward movement of duplicated centrosomes - as a central target for deregulation of bi-orientation in cancer cells. In this review, we discuss novel insights into the mechanisms that underlie centrosome dynamics and discuss how these mechanisms are perturbed in cancer cells to drive chromosome mis-segregation and advance neoplastic transformation.
引用
收藏
页码：65 / 73
页数：9
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