Safe and Efficient Reductive Methylation of Primary and Secondary Amines Using N-Methylpyrrolidine Zinc Borohydride

被引：11

作者：

Alinezhad, Heshmatollah ^{[1
]}

Tajbakhsh, Mahmood ^{[1
]}

Salehian, Fatemeh ^{[1
]}

Fazli, Kazem ^{[1
]}

机构：

[1] Mazandaran Univ, Fac Chem, Babol Sar, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 16期

关键词：

Amine; formaldehyde; reductive methylation; ZBHNMP; REDUCING AGENT;

D O I：

10.1080/00397910903249606

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, general procedure for reductive methylation of primary and secondary amines with 37% formaldehyde using N-methylpyrrolidine zinc borohydride (ZBHNMP) as a reducing agent gave the corresponding tertiary amines in excellent yields. The reaction was carried out in tetrahydrofuran under neutral conditions at 0-10 degrees C.

引用

页码：2415 / 2420

页数：6

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