Insulin-like growth factors and risk of kidney cancer in men

BACKGROUND: Insulin-like growth factor-I (IGF-I) has been shown to increase kidney growth, glomerular filtration rate, and renal function. METHODS: In the prospective Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) study of 29 133 Finnish male smokers aged 50-69 years, serum concentrations of IGF were measured in samples collected in 1985-1988. A total of 100 men with kidney cancer diagnosed >= 5 years after blood collection through 1997 were compared with a subcohort of 400 men; logistic regression models were used to estimate the risk of developing kidney cancer. RESULTS: Men with IGF-I levels > 113 ng ml(-1) were 59% less likely to develop kidney cancer than men with levels <= 113 ng ml(-1) (odds ratio = 0.41; 95% confidence interval 0.23-0.75). The IGF binding protein-3 (IGFBP-3) levels did not alter the association. No association was observed between IGFBP-3, or molar ratio of IGF-I/IGFBP-3, and kidney cancer. CONCLUSIONS: Low serum IGF-I levels in this cohort of older middle-aged male smokers are associated with increased kidney cancer risk, independent of IGFBP-3. British Journal of Cancer (2010) 103, 132-135. doi:10.1038/sj.bjc.6605722 www.bjcancer.com Published online 1 June 2010 (C) 2010 Cancer Research UK