Comparison of CD163+CD206+M2 Macrophages in the Lesional Skin of Bullous Pemphigoid and Pemphigus Vulgaris: The Possible Pathogenesis of Bullous Pemphigoid

被引：37

作者：

Furudate, Sadanori ^{[1
]}

Fujimura, Taku ^{[1
]}

Kambayashi, Yumi ^{[1
]}

Kakizaki, Aya ^{[1
]}

Aiba, Setsuya ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Dermatol, Sendai, Miyagi 9808574, Japan

来源：

DERMATOLOGY | 2014年 / 229卷 / 04期

基金：

日本学术振兴会;

关键词：

CD163+CD206+M2 macrophages; Chemokines; T helper 1/T helper 2 cells; Bullous pemphigoid; Pemphigus vulgaris; DISEASE; CCL18; ASSOCIATION; EXPRESSION; CYTOKINES; RESPONSES; TH2;

D O I：

10.1159/000365946

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: M2 macrophages play a critical role in the induction of T helper 2 (Th2) polarization. Methods: To investigate the contribution of M2 macrophages to the pathogenesis of bullous pemphigoid (BP) and pemphigus vulgaris (PV), we employed immunohistochemical staining for CD163 and CD206, as well as pSTAT1, pSTAT6, interleukin (IL)-4, IL-13, CCL17, CCL18 and Foxp3 in the lesional skin of 10 cases of BP and PV. Results: The numbers of CD163+ CD206+ M2 macrophages were higher in BP than in PV. Moreover, pSTAT6+ cells, CCL17+ cells, CCL18+ cells and Foxp3+ regulatory T cells were prominent only in the lesional skin of BP. To further investigate the function of M2 macrophages, we examined the mRNA expression and production of Th2-related chemokines from M2 macrophages in vitro, which showed a significant increase in the mRNA expression and production of CCL18 when stimulated by IL-4 or IL-13. Conclusion: Our study sheds light onto one of the possible immunological mechanisms of BP and PV. (C) 2014 S. Karger AG, Basel

引用

页码：369 / 378

页数：10

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