Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose

被引:32
作者
Ossowicz-Rupniewska, Paula [1 ]
Rakoczy, Rafal [2 ]
Nowak, Anna [3 ]
Konopacki, Maciej [2 ]
Klebeko, Joanna [1 ]
Swiatek, Ewelina [1 ]
Janus, Ewa [1 ]
Duchnik, Wiktoria [3 ]
Wenelska, Karolina [4 ]
Kucharski, Lukasz [3 ]
Klimowicz, Adam [3 ]
机构
[1] West Pomeranian Univ Technol Szczecin, Fac Chem Technol & Engn, Dept Chem Organ Technol & Polymer Mat, Piastow Ave 42, PL-71065 Szczecin, Poland
[2] West Pomeranian Univ Technol Szczecin, Fac Chem Technol & Engn, Dept Chem & Proc Engn, Piastow Ave 42, PL-71065 Szczecin, Poland
[3] Pomeranian Med Univ, Dept Cosmet & Pharmaceut Chem, Powstancow Wielkopolskich Ave 72, PL-70111 Szczecin, Poland
[4] West Pomeranian Univ Technol Szczecin, Fac Chem Technol & Engn, Dept Nanomat Physicochem, Piastow Ave 45, PL-70311 Szczecin, Poland
关键词
amino acid; bacterial cellulose; ibuprofen; non-steroidal anti-inflammatory drug; transdermal drug delivery; skin barrier; SKIN PERMEATION; EAR SKIN; MEMBRANES; PENETRATION; SOLUBILITY; MODEL;
D O I
10.3390/ijms22126252
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The potential of bacterial cellulose as a carrier for the transport of ibuprofen (a typical example of non-steroidal anti-inflammatory drugs) through the skin was investigated. Ibuprofen and its amino acid ester salts-loaded BC membranes were prepared through a simple methodology and characterized in terms of structure and morphology. Two salts of amino acid isopropyl esters were used in the research, namely L-valine isopropyl ester ibuprofenate ([ValOiPr][IBU]) and L-leucine isopropyl ester ibuprofenate ([LeuOiPr][IBU]). [LeuOiPr][IBU] is a new compound; therefore, it has been fully characterized and its identity confirmed. For all membranes obtained the surface morphology, tensile mechanical properties, active compound dissolution assays, and permeation and skin accumulation studies of API (active pharmaceutical ingredient) were determined. The obtained membranes were very homogeneous. In vitro diffusion studies with Franz cells were conducted using pig epidermal membranes, and showed that the incorporation of ibuprofen in BC membranes provided lower permeation rates to those obtained with amino acids ester salts of ibuprofen. This release profile together with the ease of application and the simple preparation and assembly of the drug-loaded membranes indicates the enormous potentialities of using BC membranes for transdermal application of ibuprofen in the form of amino acid ester salts.
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页数:18
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