Schistosoma japonicum eggs modulate the activity of CD4+ CD25+ Tregs and prevent development of colitis in mice

被引：55

作者：

Mo, Hong-mei ^{[1
]}

Liu, Wen-qi ^{[1
]}

Lei, Jia-hui ^{[1
]}

Cheng, Yu-li ^{[1
]}

Wang, Cheng-zu ^{[1
]}

Li, Yong-long ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Parasitol, Wuhan 430030, Peoples R China

来源：

EXPERIMENTAL PARASITOLOGY | 2007年 / 116卷 / 04期

关键词：

Schistosoma japonicum egg; colitis;

D O I：

10.1016/j.exppara.2007.02.009

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Crohn's disease (CD) is considered to be caused by a disorder of the immune system and helminth infections may interact with development of the disease. We induced colitis in mice by trinitrobenzenesulfonic acid (TNBS) and observed the effects of intraperitoneally injected eggs of Schistosoma japonicum on the course of the disease. The inflammation in the colon was reduced in egg-treated mice and secretion of IFN-gamma (a Th1 cytokine) by cultured spleen cells in vitro was greatly suppressed, and of IL-4, IL-5 and IL-10 (Th2 cytokines) significantly elevated after egg injection. Also, the percentage of regulatory T-cells (Tregs) was increased in the spleens of egg-exposed mice with TNBS-induced colitis compared to non-egg exposed animals. The data suggest that Tregs may be activated by S. japonicum eggs and play a role in restoring immune disorders in TNBS-induced colitis of mice. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：385 / 389

页数：5

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