Population prevalence of Down's syndrome in the United Kingdom

被引：18

作者：

Alexander, M. ^{[1
,2
]}

Ding, Y. ^{[3
]}

Foskett, N. ^{[1
,2
]}

Petri, H. ^{[4
]}

Wandel, C. ^{[5
]}

Khwaja, O. ^{[6
]}

机构：

[1] Roche Prod Ltd, Welwyn Garden City, Herts, England

[2] Roche Prod Ltd, Antrim, North Ireland

[3] Genesis Res Ltd, Richardson, TX USA

[4] Petri Consulting Ltd, 12 Coll Pl, St Albans AL3 4PU, England

[5] Roche Prod Dev, Basel, Switzerland

[6] Roche Pharmaceut Res & Early Dev, Basel, Switzerland

来源：

JOURNAL OF INTELLECTUAL DISABILITY RESEARCH | 2016年 / 60卷 / 09期

关键词：

Down's syndrome; prevalence; primary care database; BIRTH PREVALENCE; MATERNAL AGE; ENGLAND; WALES; ADULTS; TRENDS;

D O I：

10.1111/jir.12277

中图分类号：

G76 [特殊教育];

学科分类号：

040109 ;

摘要：

BackgroundAim was to estimate the age and sex-stratified prevalence of Down's syndrome (DS) in the United Kingdom (UK) general population using a large primary care database. MethodData source was the Clinical Practice Research Datalink. We divided the number of individuals with a record of DS present on 01/07/2014 by the total number of individuals, and computed Wilson's confidence intervals. Prevalence by age and sex was represented using local linear smoothing plots. ResultsOn July 1(st) 2014, 1159 females and 1317 males with DS were present in the data, corresponding to a prevalence of 5.9 per 10000 (95% CI: 5.5; 6.2) in females and 6.8 (6.5; 7.2) per 10000 in males. Prevalence of DS was increased in individuals aged 40 to 55years compared to adjacent age groups. ConclusionsA relative peak prevalence of DS at age 40-55years may be attributed to the combined effects of a rise in life expectancy and the still limited availability of selective abortion.

引用

页码：874 / 878

页数：5

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