Solubilisation of a 2,2-diphenyl-1-picrylhydrazyl radical in water by β-cyclodextrin to evaluate the radical-scavenging activity of antioxidants in aqueous media

被引：17

作者：

Nakanishi, Ikuo ^{[1
]}

Ohkubo, Kei ^{[2
,3
,4
]}

Imai, Kohei ^{[5
]}

Kamibayashi, Masato ^{[6
]}

Yoshihashi, Yasuo ^{[7
]}

Matsumoto, Ken-ichiro ^{[1
]}

Fukuhara, Kiyoshi ^{[5
]}

Terada, Katsuhide ^{[7
]}

Itoh, Shinobu ^{[2
]}

Ozawa, Toshihiko ^{[8
]}

Fukuzumi, Shunichi ^{[2
,3
,4
,9
,10
]}

机构：

[1] Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Adv Particle Radiat Biol Res Program, Radio Redox Response Res Team,Inage Ku, Chiba 2638555, Japan

[2] Osaka Univ, Grad Sch Engn, Dept Mat & Life Sci, Suita, Osaka 5650871, Japan

[3] Japan Sci & Technol Agcy JST, ALCA, Suita, Osaka 5650871, Japan

[4] Japan Sci & Technol Agcy JST, SENTAN, Suita, Osaka 5650871, Japan

[5] Showa Univ, Sch Pharm, Shinagawa Ku, Tokyo 1428555, Japan

[6] Kyoto Pharmaceut Univ, Pharmaceut Mfg Chem, Kyoto 6078414, Japan

[7] Toho Univ, Fac Pharmaceut Sci, Dept Pharmaceut, Funabashi, Chiba 2748510, Japan

[8] Showa Pharmaceut Univ, Div Oxidat Stress Res, Machida, Tokyo 1948543, Japan

[9] Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South Korea

[10] Meijo Univ, Fac Sci & Technol, Tempa Ku, Nagoya, Aichi 4688502, Japan

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 39期

关键词：

DPPH-CENTER-DOT; HYDROGEN-ATOM ABSTRACTION; ELECTRON-TRANSFER; KINETICS; SUPEROXIDE; PHENOLS; DPPH(CENTER-DOT); PARAMETERS; MECHANISMS; ASCORBATE;

D O I：

10.1039/c5cc02236c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A 2,2-diphenyl-1-picrylhydrazyl radical (DPPH center dot) was successfully solubilised in water by beta-cyclodextrin (beta-CD). DPPH center dot/beta-CD thus obtained was demonstrated to be a powerful tool to evaluate the antioxidative activity of water-soluble antioxidants, such as ascorbate and Trolox, in aqueous buffer solutions.

引用

页码：8311 / 8314

页数：4

共 38 条

[1] Proton-electron transfer pathways in the reactions of peroxyl and dpph• radicals with hydrogen-bonded phenols [J].