The use of vasopressin receptor antagonists in hyponatremia

被引：10

作者：

Elhassan, Elwaleed A. ^{[1
]}

Schrier, Robert W. ^{[1
]}

机构：

[1] Univ Colorado Denver, Div Renal Dis & Hypertens, Aurora, CO 80045 USA

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2011年 / 20卷 / 03期

关键词：

aquaretics; hyponatremia; vaptans; vasopressin receptor antagonists; INAPPROPRIATE SECRETION; ANTIDIURETIC-HORMONE; SERUM SODIUM; DEMECLOCYCLINE TREATMENT; MILD HYPONATREMIA; WATER-RETENTION; HEART-FAILURE; CONIVAPTAN; FRACTURE; ASCITES;

D O I：

10.1517/13543784.2011.553186

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Areas covered: This review presents a diagnostic approach for hyponatremia and discusses some therapeutic considerations. It displays new evidence linking mild chronic hyponatremia with unfavorable outcomes and examines the available treatment options and their limitations and strengths. New data on vaptans and their potential role to treat hyponatremia in different clinical settings are reviewed. Expert opinion: Vaptans are likely to play an important role in treating hyponatremia, given their clinical efficacy and tolerability. High cost remains an impediment for vaptans, and more studies are needed to further define their best use in hyponatremic patients.

引用

页码：373 / 380

页数：8

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