Encoding Allostery in mTOR Signaling: The Structure of the Rag GTPase/Ragulator Complex

被引：8

作者：

Cherfils, Jacqueline ^{[1
,2
]}

机构：

[1] CNRS, Lab Biol & Pharmacol Appl, Cachan, France

[2] Ecole Normale Super Paris Saclay, Cachan, France

来源：

MOLECULAR CELL | 2017年 / 68卷 / 05期

关键词：

CRYSTAL-STRUCTURE; REVEALS;

D O I：

10.1016/j.molcel.2017.11.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Molecular Cell, Su et al. (2017) describe the structure of the Rag/Ragulator complex, a key relay in nutrient sensing by mTOR. The structure sheds new light on how signals are conveyed from the lysosome to mTOR.

引用

页码：823 / 824

页数：2

共 10 条

[1] Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels tomTORC1 [J].

Bar-Peled, Liron ;

Schweitzer, Lawrence D. ;

Zoncu, Roberto ;

Sabatini, David M. .

CELL, 2012, 150 (06) :1196-1208

[2]

Brady O.A., 2011, NATURE, V477, P611

[3] Conformational changes in the G protein Gs induced by the β2 adrenergic receptor [J].

Chung, Ka Young ;

Rasmussen, Soren G. F. ;

Liu, Tong ;

Li, Sheng ;

DeVree, Brian T. ;

Chae, Pil Seok ;

Calinski, Diane ;

Kobilka, Brian K. ;

Woods, Virgil L., Jr. ;

Sunahara, Roger K. .

NATURE, 2011, 477 (7366) :611-U143

[4] Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling [J].

de Araujo, Mariana E. G. ;

Naschberger, Andreas ;

Fuernrohr, Barbara G. ;

Stasyk, Taras ;

Dunzendorfer-Matt, Theresia ;

Lechner, Stefan ;

Welti, Stefan ;

Kremser, Leopold ;

Shivalingaiah, Giridhar ;

Offterdinger, Martin ;

Lindner, Herbert H. ;

Huber, Lukas A. ;

Scheffzek, Klaus .

SCIENCE, 2017, 358 (6361) :377-+

[5] Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation [J].

Gong, Rui ;

Li, Li ;

Liu, Yi ;

Wang, Ping ;

Yang, Huirong ;

Wang, Ling ;

Cheng, Jingdong ;

Guan, Kun-Liang ;

Xu, Yanhui .

GENES & DEVELOPMENT, 2011, 25 (16) :1668-1673

[6] Crystal Structure of the Gtr1pGTP-Gtr2pGDP Protein Complex Reveals Large Structural Rearrangements Triggered by GTP-to-GDP Conversion [J].

Jeong, Jae-Hee ;

Lee, Kwang-Hoon ;

Kim, Young-Mi ;

Kim, Do-Hyung ;

Oh, Byung-Ha ;

Kim, Yeon-Gil .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (35) :29648-29653

[7]

Levine Timothy P, 2013, Small GTPases, V4, P62, DOI 10.4161/sgtp.24262

[8] Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor [J].

Renault, L ;

Guibert, B ;

Cherfils, J .

NATURE, 2003, 426 (6966) :525-530

[9] Twenty-five years of mTOR: Uncovering the link from nutrients to growth [J].

Sabatini, David M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (45) :11818-11825

[10]

TITLE ERROR

← 1 →