Probing Chiral Recognition of Enzyme Active Sites with Octahedral Iridium(III) Propeller Complexes

被引：20

作者：

Goebel, Peter ^{[1
]}

Ritterbusch, Florian ^{[1
]}

Helms, Melanie ^{[1
]}

Bischof, Matthias ^{[1
]}

Harms, Klaus ^{[1
]}

Jung, Manfred ^{[2
]}

Meggers, Eric ^{[1
,3
]}

机构：

[1] Univ Marburg, Fachbereich Chem, Hans Meerwein Str, D-35043 Marburg, Germany

[2] Univ Freiburg, Inst Pharmaceut Sci, D-79104 Freiburg, Germany

[3] Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2015年 / 10期

关键词：

Enzyme inhibitors; Iridium; Chirality; Molecular recognition; Metal-centered configuration; METAL-COMPLEXES; ORGANOMETALLIC COMPOUNDS; ASYMMETRIC-SYNTHESIS; INHIBITORS; FERROCENE; CHEMISTRY; DISCOVERY; AGENTS; IX;

D O I：

10.1002/ejic.201500087

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral bis-cyclometalated octahedral organoiridium(III) complexes were designed to target different classes of enzymes, namely carbonic anhydrases, histone deacetylases, and serine proteases. The stereoselective non-racemic synthesis of selected complexes was used to study the chiral discrimination of enzyme active sites for enantiomers of propeller-type octahedral metal complexes. Cases for negligible, modest, and significant chiral discrimination in the interaction of iridium propeller complexes with enzyme active sites were identified.

引用

页码：1654 / 1659

页数：6

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