Photophysico-chemical properties and photoinactivation of Staphylococcus Aureus using zinc phthalocyanines linked silver nanoparticles conjugates

被引：9

作者：

Matlou, Gauta Gold ^{[1
]}

Nyokong, Tebello ^{[1
]}

机构：

[1] Rhodes Univ, Inst Nanotechnol Innovat, Dept Chem, ZA-6140 Grahamstown, South Africa

来源：

DYES AND PIGMENTS | 2020年 / 176卷

基金：

新加坡国家研究基金会;

关键词：

Zinc phthalocyanines; Silver nanoparticle staphylococcus Aureus; Singlet oxygen quantum yield; Photodynamic antimicrobial chemotherapy; PHOTODYNAMIC ANTIMICROBIAL CHEMOTHERAPY; CINNAMIC ACID; METAL PHTHALOCYANINES; WATER; THERAPY; PHOTOSENSITIZERS; INACTIVATION; SUBSTITUENTS; DERIVATIVES; ABSORPTION;

D O I：

10.1016/j.dyepig.2020.108237

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The synthesis of zinc (II) tri (tert-butyl phenoxy) mono cinnamic acid Pc (complex 1) is reported for the first time in this work. Complex 1 and the reported zinc (II) tri (tert-butyl), mono cinnamic acid phthalocyanine (2), zinc (II) mono cinnamic acid substituted phthalocyanine (3) and zinc (II) tetra cinnamic acid substituted phthalocyanine (4) are conjugated to cysteine capped silver nanoparticles (cys-AgNPs) through an amide bond. The photophysicochemical properties and the photodynamic antimicrobial chemotherapy (PACT) activities of the Pc-cys-AgNPs conjugates and the Pcs alone on S. Aureus are reported. Improved triplet and singlet oxygen quantum yields were observed for the conjugated complexes compared to Pcs alone, due to the heavy atom effect of cys-AgNPs. Asymmetric complexes 1,2, 3 and their respective conjugates recorded higher photosensitizing properties and PACT activities compared to 4 and 4-cys-AgNPs, respectively. Higher log reductions and percentage reductions of S. Aureus were recorded for conjugated complexes compared to ZnPcs only, showing enhanced PACT activities due to their higher singlet oxygen quantum yields.

引用

页数：11

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