Distinct intrathecal interleukin-17/interleukin-6 activation in anti-N-methyl-D-aspartate receptor encephalitis

被引：60

作者：

Byun, Jung-Ick ^{[1
,2
,3
]}

Lee, Soon-Tae ^{[1
,2
]}

Moon, Jangsup ^{[1
,2
]}

Jung, Keun-Hwa ^{[1
,2
]}

Sunwoo, Jun-Sang ^{[1
,2
,4
]}

Lim, Jung-Ah ^{[1
,2
]}

Kim, Tae-Joon ^{[1
,2
]}

Shin, Yong-Won ^{[1
,2
]}

Lee, Keon-Joo ^{[1
,2
]}

Jun, Jin-Sun ^{[1
,2
]}

Lee, Han Sang ^{[1
,2
]}

Lee, Woo-Jin ^{[1
,2
]}

Kim, Young-Sook ^{[2
]}

Kim, Soyun ^{[2
]}

Jeon, Daejong ^{[5
]}

Park, Kyung-Il ^{[1
,2
,6
]}

Jung, Ki-Young ^{[1
,2
]}

Kim, Manho ^{[1
,2
]}

Chu, Kon ^{[1
,2
]}

Lee, Sang Kun ^{[1
,2
]}

机构：

[1] Seoul Natl Univ Hosp, Dept Neurol, Seoul, South Korea

[2] Seoul Natl Univ, Program Neurosci, Coll Med, Seoul, South Korea

[3] Kyung Hee Univ Hosp Gangdong, Dept Neurol, Seoul, South Korea

[4] Soonchunhyang Univ, Dept Neurol, Sch Med, Seoul, South Korea

[5] Adv Neural Technol Co, Seoul, South Korea

[6] Seoul Natl Univ Hospita, Dept Neurol, Healthcare Syst Gangnam Ctr, Seoul, South Korea

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 297卷

关键词：

Cytokine; Autoimmune encephalitis; NMDAR; LGI1; IL-17A; IL-6; CXCL13; T-CELLS; INTERLEUKIN-2; MECHANISMS; PROFILES; CYTOKINE; BLOCKADE; SPECTRUM; PATIENT;

D O I：

10.1016/j.jneuroim.2016.05.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this study was to compare serum and cerebrospinal fluid (CSF) cytokine/chemokine levels between anti-NMDAR and anti-LGI1 encephalitis patients. Samples from fourteen anti-NMDAR encephalitis patients, ten anti-LGI1 encephalitis patients, and ten controls were analyzed for the following cytokines/chemokines: IL-1b, IL-2, IL-4, IL-5, IL-6,IL-10, IL-12, IL-13, IL-17A, IL-23, GM-CSF, IFN-gamma, TNF-alpha, and CXCL13. Compared with controls, CSF IL-17A, IL-6 and CXCL13 were elevated in anti-NMDAR encephalitis patients (post-hoc p-values 0.002, 0.011, and 0.011, respectively) but not in anti-LGI1 encephalitis patients. In the serum, only IL-2 was increased in anti-NMDAR encephalitis. Intrathecal IL-17/IL-6 activation is a characteristic of anti-NMDAR encephalitis. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：141 / 147

页数：7

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