Vicinal amino alcohols as organocatalysts in asymmetric cross-aldol reaction of ketones:: Application in the synthesis of convolutamydine a

被引：167

作者：

Malkov, Andrei V. ^{[1
]}

Kabeshov, Mikhail A. ^{[1
]}

Bella, Marco ^{[1
]}

Kysilka, Ondrej ^{[1
]}

Malyshev, Denis A. ^{[1
]}

Pluhackova, Kristyna ^{[1
]}

Kocovsky, Pavel ^{[1
]}

机构：

[1] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 26期

关键词：

D O I：

10.1021/ol7023983

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Leucinol and valinol have been identified as efficient organocatalysts for the aldol reaction of isatin and its derivatives (as examples of activated, non-enolizable ketones) with acetone. Uncommon mechanistic features were observed and used in the formulation of the transition state of the reaction.

引用

页码：5473 / 5476

页数：4

共 46 条

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