Expression of hMSH2 and hMLH1 proteins of the human DNA mismatch repair system in ameloblastoma

被引：15
作者：
Castrilli, G
Piantelli, M
Artese, L
Perfetti, G
Rubini, C
Fioroni, M
Ranelletti, FO
Piattelli, A
机构：
[1] UCL Eastman Dent Inst Oral Hlth Care Sci, London, England
[2] Univ Cattolica Sacro Cuore, Dept Histol, I-00168 Rome, Italy
[3] Univ Ancona, Sch Dent, Ancona, Italy
[4] Univ Ancona, Dept Pathol Anat & Histopathol, Ancona, Italy
[5] Univ G dAnnunzio, Sch Dent, Chieti, Italy
[6] Univ G dAnnunzio, Dept Oncol, Chieti, Italy
来源：
JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2001年 / 30卷 / 05期
关键词：
ameloblastoma; hMMR; jaw tumors;
D O I：
10.1034/j.1600-0714.2001.300508.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The human DNA mismatch repair (hMMR) system plays an important role in reducing mutation and maintaining genomic stability. The MMR system in human cells is composed of at least six genes (hMSH2, hMLH1, hMSH3, hPMS1, hPMS2 and GTBP/hMSH6). in particular, hMSH2 and hMLH1 are expressed in human cells that are undergoing rapid renewal; their reduced expresion has been reported in several tumors. We examined the protein expression pattern of hMSH2 and hMLH1 by immunohistochemistry in 25 ameloblastomas. All ameloblastomas expressed hMSH2 and hMLH1 proteins in the outer layer of epithelial cells. The localization of the staining was exclusively nuclear. These data suggest that the development and progression of these tumors do not depend on a defect in the hMMR system.
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收藏
页码：305 / 308
页数：4
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