Does the relative risk for type 1 diabetes conferred by HLA-DQ, INS, and PTPN22 polymorphisms vary with maternal age, birth weight, or cesarean section?

被引：8

作者：

Stene, Lars C. ^{[1
,2
]}

Ronningen, Kjersti S. ^{[1
]}

Undlien, Dag E. ^{[3
,4
]}

Joner, Geir ^{[2
,5
,6
]}

机构：

[1] Norwegian Inst Publ Hlth, Div Epidemiol, NO-0403 Oslo, Norway

[2] Oslo Univ Hosp, Oslo Diabet Res Ctr, Oslo, Norway

[3] Univ Oslo, Fac Div Oslo Univ Hosp Ulleval, Inst Med Genet, Oslo, Norway

[4] Oslo Univ Hosp Ulleval, Dept Med Genet, Oslo, Norway

[5] Oslo Univ Hosp Ulleval, Dept Pediat, Oslo, Norway

[6] Univ Oslo, Inst Hlth Management & Hlth Econ, Oslo, Norway

来源：

PEDIATRIC DIABETES | 2011年 / 12卷 / 02期

关键词：

diabetes in childhood; epidemiology; genetics; gene-environment interaction; genetics of type 1 diabetes; human; INTESTINAL MICROBIOTA; CHILDHOOD; METAANALYSIS; DELIVERY;

D O I：

10.1111/j.1399-5448.2010.00669.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and objective: Maternal age at birth, birth weight, and cesarean section has been associated with a weak but significant increase in risk of type 1 diabetes. The objective was to assess whether the relative risk for type 1 diabetes conferred by established susceptibility loci human leukocyte antigen (HLA)-DQ, INS, and PTPN22 differed depending on these perinatal factors. Methods: We employed a case-control study with 456 cases of type 1 diabetes diagnosed before 15 yr of age and 1377 population-based control children. HLA genotypes were divided into high to moderate risk (DQ8/DQ2, DQ8/DQ8, DQ8/X, DQ2/DQ2) vs. all other genotypes. Case-only analysis using logistic regression was used to test for significant interaction. Results: There was no significant difference in the relative risks conferred by HLA-DQ, INS, or PTPN22 by maternal age, birth weight, or mode of delivery, except the relative risk conferred by PTPN22 which was 2.11 [95% confidence interval (CI): 1.64-2.72] for those born vaginally and 0.99 (95% CI: 0.50-1.99) for those born by cesarean section [p(interaction) = 0.028]. Conclusion: The relative risks conferred by the three established susceptibility genes investigated here were independent of the perinatal factors, apart from a possible interaction between PTPN22 and mode of delivery.

引用

页码：91 / 94

页数：4

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