The Role of Lipoprotein-Associated Phospholipase A2 as a Marker and Potential Therapeutic Target in Atherosclerosis

被引：22

作者：

Stewart, Ralph A. H. ^{[1
]}

White, Harvey D. ^{[1
]}

机构：

[1] Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland 1030, New Zealand

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2011年 / 13卷 / 02期

关键词：

darapladib; Lp-PLA(2); plaque stabilization; atherosclerosis; cardiovascular disease; ACTIVATING-FACTOR-ACETYLHYDROLASE; CORONARY-HEART-DISEASE; LOW-DENSITY-LIPOPROTEIN; PLASMA; RISK; EXPRESSION; DARAPLADIB; PLAQUE; LYSOPHOSPHATIDYLCHOLINE; INHIBITOR;

D O I：

10.1007/s11883-010-0158-8

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that generates inflammatory mediators within atherosclerotic plaques. In epidemiologic studies there is an association between higher plasma Lp-PLA(2) activity and myocardial infarction, stroke and cardiovascular mortality. In animal models, darapladib, a specific inhibitor of Lp-PLA(2,) decreases the size of the atheroma necrotic core and plaques with thin fibrous caps. Early clinical trials suggest darapladib effectively and safely inhibits Lp-PLA(2) activity both in plasma and in carotid atheroma. Two large phase III clinical trials that are currently in progress will determine whether darapladib will reduce the risk of myocardial infarction, stroke, and cardiovascular death by stabilizing atherosclerotic plaques.

引用

页码：132 / 137

页数：6

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