Computer-Aided Detection (CADe) System with Optical Coherent Tomography for Melanin Morphology Quantification in Melasma Patients

被引：17

作者：

Chen, I-Ling ^{[1
]}

Wang, Yen-Jen ^{[2
,3
]}

Chang, Chang-Cheng ^{[4
,5
,6
,7
]}

Wu, Yu-Hung ^{[2
,8
]}

Lu, Chih-Wei ^{[1
]}

Shen, Jia-Wei ^{[5
]}

Huang, Ling ^{[1
]}

Lin, Bor-Shyh ^{[4
]}

Chiang, Hsiu-Mei ^{[5
]}

机构：

[1] Apollo Med Opt Ltd, Taipei 11491, Taiwan

[2] MacKay Mem Hosp, Dept Dermatol, Taipei 10449, Taiwan

[3] MacKay Jr Coll Med Nursing & Management, Dept Cosmet Applicat & Management, New Taipei 25245, Taiwan

[4] Natl Yang Ming Chiao Tung Univ, Inst Imaging & Biomed Photon, Tainan 71150, Taiwan

[5] China Med Univ, Dept Cosmeceut, Taichung 40433, Taiwan

[6] China Med Univ, China Med Univ Hosp, Coll Med, Sch Med, Taichung 404332, Taiwan

[7] China Med Univ Hosp, Aesthet Med Ctr, Taichung 40402, Taiwan

[8] Mackay Med Coll, Dept Med, New Taipei 25245, Taiwan

来源：

DIAGNOSTICS | 2021年 / 11卷 / 08期

关键词：

melasma; melanin; optical coherence tomography; cellular resolution; full-field OCT; photoaging; deep learning; image denoising; convolutional neural networks; computer-aided detection; REFLECTANCE CONFOCAL MICROSCOPY; IN-VIVO; MELANOSOME DISTRIBUTION; SKIN; KERATINOCYTES; MELANOCYTES; DIAGNOSIS;

D O I：

10.3390/diagnostics11081498

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dark skin-type individuals have a greater tendency to have pigmentary disorders, among which melasma is especially refractory to treat and often recurs. Objective measurement of melanin amount helps evaluate the treatment response of pigmentary disorders. However, naked-eye evaluation is subjective to weariness and bias. We used a cellular resolution full-field optical coherence tomography (FF-OCT) to assess melanin features of melasma lesions and perilesional skin on the cheeks of eight Asian patients. A computer-aided detection (CADe) system is proposed to mark and quantify melanin. This system combines spatial compounding-based denoising convolutional neural networks (SC-DnCNN), and through image processing techniques, various types of melanin features, including area, distribution, intensity, and shape, can be extracted. Through evaluations of the image differences between the lesion and perilesional skin, a distribution-based feature of confetti melanin without layering, two distribution-based features of confetti melanin in stratum spinosum, and a distribution-based feature of grain melanin at the dermal-epidermal junction, statistically significant findings were achieved (p-values = 0.0402, 0.0032, 0.0312, and 0.0426, respectively). FF-OCT enables the real-time observation of melanin features, and the CADe system with SC-DnCNN was a precise and objective tool with which to interpret the area, distribution, intensity, and shape of melanin on FF-OCT images.

引用

页数：13

共 37 条

[21] The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes [J].