Lipid oxidation by hypochlorous acid: chlorinated lipids in atherosclerosis and myocardial ischemia

被引：67
作者：
Ford, David A. [1 ]
机构：
[1] St Louis Univ, Sch Med, Cardiovasc Res Ctr, Dept Biochem & Mol Biol, St Louis, MO 63104 USA
来源：
CLINICAL LIPIDOLOGY | 2010年 / 5卷 / 06期
关键词：
atherosclerosis; fatty acid; fatty aldehyde; lipid monocyte; myeloperoxidase; myocardial ischemia; neutrophil; plasmalogen; LOW-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; VINYL ETHER BOND; ABCA1-DEPENDENT CHOLESTEROL TRANSPORT; MYELOPEROXIDASE-CATALYZED OXIDATION; CARDIAC SARCOPLASMIC-RETICULUM; PLATELET-ACTIVATING-FACTOR; PEROXIDE-CHLORIDE SYSTEM; ACUTE CORONARY SYNDROMES; SCAVENGER RECEPTOR CD36;
D O I：
10.2217/CLP.10.68
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Leukocytes, containing myeloperoxidase (MPO), produce the reactive chlorinating species, HOCl and they have important roles in the pathophysiology of cardiovascular disease. Leukocyte-derived HOCl can target primary amines, alkenes and vinyl ethers of lipids, resulting in chlorinated products. Plasmalogens are vinyl ether-containing phospholipids that are abundant in tissues of the cardiovascular system. The HOCl oxidation products derived from plasmalogens are alpha-chlorofatty aldehyde and unsaturated molecular species of lysophosphatidylcholine; alpha-chlorofatty aldehyde is the precursor of both alpha-chlorofatty alcohol and alpha-chlorofatty acid. Both alpha-chlorofatty aldehyde and alpha-chlorofatty acid accumulate in activated neutrophils and have disparate chemotactic properties. In addition, alpha-chlorofatty aldehyde increases in activated monocytes, human atherosclerotic lesions and rat infarcted myocardium. This article addresses the pathways for the synthesis of these lipids and their biological targets.
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页码：835 / 852
页数：18
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