Discovery of S-phase arresting agents derived from noscapine

被引：40

作者：

Anderson, JT ^{[1
]}

Ting, AE ^{[1
]}

Boozer, S ^{[1
]}

Brunden, KR ^{[1
]}

Danzig, J ^{[1
]}

Dent, T ^{[1
]}

Harrington, JJ ^{[1
]}

Murphy, SM ^{[1
]}

Perry, R ^{[1
]}

Raber, A ^{[1
]}

Rundlett, SE ^{[1
]}

Wang, JM ^{[1
]}

Wang, N ^{[1
]}

Bennani, YL ^{[1
]}

机构：

[1] Athersys Inc, Cleveland, OH 44115 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 48卷 / 08期

关键词：

D O I：

10.1021/jm0494220

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogues of the natural product noscapine were synthesized, and their potential as antitumor agents were examined. The discovery of a novel regio- and stereoselective O-demethylation led to the synthesis of several O-alkylated analogues that induced an unexpected S-phase arrest of mammalian cells. Compound 4a was the most potent analogue inhibiting cell proliferation at an EC50 of 1.9 mu M.

引用

页码：2756 / 2758

页数：3

共 14 条

[1] PHARMACOKINETIC PROPERTIES OF NOSCAPINE [J].