Neural Injury, Repair, and Adaptation in the GI Tract III. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system

被引：33

作者：

Pachnis, V ^{[1
]}

Durbec, P ^{[1
]}

Taraviras, S ^{[1
]}

Grigoriou, M ^{[1
]}

Natarajan, D ^{[1
]}

机构：

[1] Natl Inst Med Res, Div Dev Neurobiol, London NW7 1AA, England

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 1998年 / 275卷 / 02期

关键词：

RET tyrosine kinase receptor; glial cell line-derived neurotrophic factor; enteric nervous system;

D O I：

10.1152/ajpgi.1998.275.2.G183

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The enteric nervous system (ENS) in vertebrates is derived from the neural crest and constitutes the most complex part of the peripheral nervous system. Natural and induced mutagenesis in mammals has shown that the tyrosine kinase receptor RET and its functional ligand glial cell line-derived neurotrophic factor (GDNF) play key roles in the development of the ENS in humans and mice. We have developed and briefly describe here a number of assays that analyze the specific function of the RET receptor and its ligand. Our data suggest that the RET signal transduction pathway has multiple roles in the development of the mammalian ENS.

引用

页码：G183 / G186

页数：4

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