Geometric considerations of micro- to nanoscale elastomeric post arrays to study cellular traction forces

被引：131

作者：

Yang, Michael T. ^{[1
]}

Sniadecki, Nathan J. ^{[1
]}

Chen, Christopher S. ^{[1
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 20期

关键词：

D O I：

10.1002/adma.200701956

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Micro- to nanoscale elastomeric post arrays with different post geometries were used to probe the effects of local substrate architecture on cell spreading and traction force generation in adherent cells (see figure). As post density increases, cell morphology on the post arrays increasingly resembles that of cells on continuous substrates. In addition, contractile strain energy generated by cells remained constant across substrates with different post stiffness or adhesive surface area.

引用

页码：3119 / +

页数：6

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