Comparative study of anti-VEGF Ranibizumab and Interleukin-6 receptor antagonist Tocilizumab in Adjuvant-induced Arthritis

被引：24

作者：

Abdel-Maged, Amany El-Shahawy ^{[1
]}

Gad, Amany M. ^{[2
]}

Abdel-Aziz, Amal Kamal ^{[3
]}

Aboulwafa, Mohammad M. ^{[4
]}

Azab, Samar S. ^{[3
]}

机构：

[1] NORCB, Cairo, Egypt

[2] NODCAR, Dept Pharmacol, Cairo, Egypt

[3] Ain Shams Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo 11566, Egypt

[4] Ain Shams Univ, Fac Pharm, Dept Microbiol & Immunol, Cairo, Egypt

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 2018年 / 356卷

关键词：

Adjuvant induced arthritis; Ranibizumab; Tocilizumab; Immune Response; ENDOTHELIAL GROWTH-FACTOR; COLLAGEN-INDUCED ARTHRITIS; RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; INADEQUATE RESPONDERS; RAT MODEL; ANGIOGENESIS; METHOTREXATE; EXPRESSION; BONE;

D O I：

10.1016/j.taap.2018.07.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Although the precise etiology of Rheumatoid arthritis (RA) remains obscure, heightened immune response is thought to play a vital role in provoking joint inflammation and bone erosion. This study aims at comparatively evaluating the effects of two monoclonal antibodies Ranibizumab (RANI) as anti-VEGF antibody and Tocilizumab (TCZ) as interleukin-6 receptor (IL-6R) antagonist, against adjuvant induced arthritis in rats. CFA-induced arthritic rats were treated for three consecutive weeks with Methotrexate (MTX), TCZ and RANI monotherapy. Clinical assessment of RA, bone erosion, inflammatory, angiogenic and apoptotic markers were determined to assess the anti-arthritic effect. Liver enzymes and histopathological examination of liver and spleen were assessed to evaluate the toxicity profile of the tested therapeutic agents. MTX, TCZ and RANI monotherapy significantly enhanced the anti-arthritic parameters in comparison with the Complete Freund's Adjuvant (CFA)-induced arthritic rats through significant reduction of ankle and paw swelling. Also, they significantly reduced inflammatory, angiogenic and apoptotic markers. Importantly, Ranibizumab showed better effect than the standard anti-rheumatic drugs Methotrexate (MTX) or Tocilizumab (TCZ) in bone protection and cartilage health; hence proves to be a promising new therapeutic agent for RA.

引用

页码：65 / 75

页数：11

共 64 条

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