Decreased plasma cortisol level during alprazolam treatment of panic disorder: A case report

被引：4

作者：

Fukuda, M

Takazawa, S

Nakagome, K

Iwanami, A

Hata, A

Kasai, K

Hiramatsu, K

机构：

[1] Univ Tokyo, Fac Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138655, Japan

[2] Teikyo Univ, Sch Med, Dept Psychiat, Tokyo 173, Japan

[3] Showa Univ, Sch Med, Dept Psychiat, Tokyo 142, Japan

[4] Musashi Hosp, Natl Ctr Neurol & Psychiat, Tokyo, Japan

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1998年 / 22卷 / 05期

关键词：

alprazolam; cortisol; panic disorder;

D O I：

10.1016/S0278-5846(98)00047-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment (mean 0.62+/-0.15 mg/day) compared with during the period of high-dose period (mean 1.08+/-0.28 mg/day). 2. The plasma cortisol level was significantly higher in the low-dose period (mean 13.90+/-3.35 ug/ml) than in the high-dose period (mean 9.06+/-2.75 ug/ml) although, paradoxically, the panic attack frequency was significantly lower in the low-dose period (mean 1.35+/-0.29/day) than in the high-dose period (mean 2.09+/-0.66/day). 3. Thus, the decreased plasma cortisol level during alprazolam treatment of panic disorder was suggested to be caused not by symptom alleviation due to alprazolam but by alprazolam administration itself.

引用

页码：909 / 915

页数：7

共 18 条

[1]

Abelson JL, 1996, ARCH GEN PSYCHIAT, V53, P323

[2] Hypothalamic-pituitary-adrenal axis activity in panic disorder: Effects of alprazolam on 24 h secretion of adrenocorticotropin and cortisol [J].