In this research, the synthesis of pyrido[2,3-d:5,6-d']dipyrimidines by CuFe2O4/KCC-1/PMA magnetic nanoparticles was reported. Synthesis of pyrido[2,3-d:5,6-d']dipyrimidines was performed under solvent-free conditions with good to excellent yields. The prepared nanocatalyst was synthesized in three steps and also was characterized by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), vibrating sample magnetometry (VSM), and N-2 adsorption-desorption measurement (Brunauer-Emmett-Teller [BET]) analyses. In addition, the reusability studies of CuFe2O4/KCC-1/PMA showed that the recovered catalyst could be used for several times.