Preparation and drug delivery of dextran-drug complex

被引：72

作者：

Huang, Shiyu ^{[1
]}

Huang, Gangliang ^{[1
]}

机构：

[1] Chongqing Normal Univ, Chongqing Key Lab Inorgan Funct Mat, Act Carbohydrate Res Inst, Chongqing 401331, Peoples R China

来源：

DRUG DELIVERY | 2019年 / 26卷 / 01期

关键词：

Dextran-drug complex; preparation; magnetic targeting; drug delivery; CROSS-LINKED DEXTRAN; CONTROLLED-RELEASE; IN-VITRO; TRANSFORMING GROWTH-FACTOR-BETA-1; VERSATILE FUNCTIONALIZATION; MICROSPHERES; HYDROGELS; NANOPARTICLES; GELATIN; GENE;

D O I：

10.1080/10717544.2019.1580322

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dextran as a drug carrier for inhibiting cancer cells effectively reduces the toxic and side effects of the drug in the biological body. Targeting improves the concentration of active substance around the target tissue, which reduces damage to other heavy organs and other normal tissues. Dextran will be a potential carrier for the delivery of antitumor drugs in the future, which provides the possibility of slow-release chemotherapy and targeted drug delivery. Herein, the preparation and drug delivery of dextran-drug complex were summarized and discussed in detail.

引用

页码：252 / 261

页数：10

共 64 条

[1]

[Anonymous], CHIN J MED CHEM

[2]

Bao FJ, 2010, THESIS

[3] Release characteristics of salmon calcitonin from dextran hydrogels for colon-specific delivery [J].

Basan, Hasan ;

Gumusderelioglu, Menemse ;

Orbey, M. Tevfik .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2007, 65 (01) :39-46

[4] Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity [J].

Bedia, Kocyigit-Kaymakcioglu ;

Elcin, Oruc ;

Seda, Unsalan ;

Fatma, Kandemirli ;

Nathaly, Shvets ;

Sevim, Rollas ;

Dimoglo, Anatholy .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (11) :1253-1261

[5] Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro [J].

Berry, CC ;

Wells, S ;

Charles, S ;

Curtis, ASG .

BIOMATERIALS, 2003, 24 (25) :4551-4557

[6] FIXATION OF VARIOUS ALDEHYDIC DEXTRANS ONTO HUMAN HEMOGLOBIN - STUDY OF CONJUGATE STABILITY [J].

BONNEAUX, F ;

DELLACHERIE, E .

JOURNAL OF PROTEIN CHEMISTRY, 1995, 14 (01) :1-5

[7] In situ crosslinked biodegradable hydrogels loaded with IL-2 are effective tools for local IL-2 therapy [J].

Bos, GW ;

Jacobs, JJL ;

Koten, JW ;

Van Tomme, S ;

Veldhuis, T ;

van Nostrum, CF ;

Den Otter, W ;

Hennink, WE .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2004, 21 (04) :561-567

[8] Crosslinked dextran - a new capsule material for colon targeting of drugs [J].

Brondsted, H ;

Andersen, C ;

Hovgaard, L .

JOURNAL OF CONTROLLED RELEASE, 1998, 53 (1-3) :7-13

[9]

Cadée JA, 2001, J BIOMED MATER RES, V56, P600, DOI 10.1002/1097-4636(20010915)56:4<600::AID-JBM1133>3.0.CO

[10]

2-I

← 1 2 3 4 5 6 7 →