The Relation between Childhood Obesity and MC4R Gene and Near MC4R Polymorphisms

被引：0
|
作者：
Erkal, Ozgur [1 ,2 ]
Ergun, Mehmet Ali [1 ]
Boyraz, Mehmet [3 ]
Bideci, Aysun [3 ]
Cinaz, Peyami [3 ]
机构：
[1] Gazi Univ, Dept Med Genet, Fac Med, Ankara, Turkey
[2] Minist Hlth Antalya Educ & Res Hosp, Dept Genet, Antalya, Turkey
[3] Gazi Univ, Dept Pediat Endocrinol, Fac Med, Ankara, Turkey
来源：
GAZI MEDICAL JOURNAL | 2020年 / 31卷 / 01期
关键词：
Childhood obesity; MC4R; polymorphism; PCR; RFLP; MELANOCORTIN-4; RECEPTOR; COMMON VARIANTS; MUTATIONS; RISK; FAT; CHILDREN; WEIGHT; ENERGY;
D O I：
10.12996/gmj.2020.24
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Childhood obesity, especially in the developed countries including all over the world has an increasing prevalence. Regarding the major impact on public health perspective, childhood obesity should be monitored closely. Many researchers reported MC4R gene and near MC4R region polymorphisms to predispose monogenic obesity both in children and adults. In this study we investigated the relation between childhood obesity and Ser58Cys, Val50Met, Ile102Ser, Val103Ile, Asn274Ser, rs17782313 and rs17700633 polymorphisms in MC4R gene and near MC4R region in the Turkish population. It is very important to detect single gene disorders that may cause childhood obesity in order to screen children for the predisposition of obesity, as to protect them from environmental factors that may cause weight gain.
引用
收藏
页码：83 / 85
页数：3
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