TT dinucleotides containing an isoxazoline moiety: Synthesis and binding affinity study

被引：11

作者：

Kong, JR

Kim, SK

Moon, BJ

Kim, SJ

Kim, BH ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Ctr Integrated Mol Syst, Pohang 790784, South Korea

[2] Kyungpook Natl Univ, Coll Nat Sci, Dept Biochem, Taegu 702701, South Korea

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 10-11期

关键词：

D O I：

10.1081/NCN-100107187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have prepared four diastereomers of TT dinucleotides containing an isoxazoline moiety and four dodecanucleotides incorporating these TT dinucleotides in the middle of the DNA sequence. We also have determined the melting temperatures of these modified oligonucleotides (Tin values) by measuring change in UV absorbance.

引用

页码：1751 / 1760

页数：10

共 6 条

[1] ANTISENSE OLIGONUCLEOTIDES [J].