Building and maintaining the epithelium of the lung

被引：188
作者：
Rackley, Craig R. [1 ]
Stripp, Barry R. [1 ,2 ]
机构：
[1] Duke Univ, Med Ctr, Dept Med, Div Pulm Allergy & Crit Care, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2012年 / 122卷 / 08期
关键词：
BRONCHIOALVEOLAR STEM-CELLS; HUMAN AIRWAY EPITHELIUM; CLARA CELL; BASAL-CELLS; NEUROEPITHELIAL BODIES; IN-VITRO; BRONCHOPULMONARY DYSPLASIA; BRONCHIAL EPITHELIUM; MAMMALIAN LUNG; MOUSE TRACHEA;
D O I：
10.1172/JCI60519
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Airspaces of the lung are lined by an epithelium whose cellular composition changes along the proximal-to-distal axis to meet local functional needs for mucociliary clearance, hydration, host defense, and gas exchange. Advances in cell isolation, in vitro culture techniques, and genetic manipulation of animal models have increased our understanding of the development and maintenance of the pulmonary epithelium. This review discusses basic cellular mechanisms that regulate establishment of the conducting airway and gas exchange systems as well as the functional maintenance of the epithelium during postnatal life.
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页码：2724 / 2730
页数：7
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