Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol

被引：236

作者：

van den Heuvel-Eibrink, Marry M. ^{[1
]}

Hol, Janna A. ^{[1
]}

Pritchard-Jones, Kathy ^{[2
]}

van Tinteren, Harm ^{[3
]}

Furtwangler, Rhoikos ^{[4
]}

Verschuur, Arnauld C. ^{[5
]}

Vujanic, Gordan M. ^{[6
]}

Leuschner, Ivo ^{[7
]}

Brok, Jesper ^{[2
]}

Rube, Christian ^{[8
]}

Smets, Anne M. ^{[9
]}

Janssens, Geert O. ^{[1
,10
]}

Godzinski, Jan ^{[11
,12
]}

Ramirez-Villar, Gema L. ^{[13
]}

de Camargo, Beatriz ^{[14
]}

Segers, Heidi ^{[15
]}

Collini, Paola ^{[16
]}

Gessler, Manfred ^{[17
]}

Bergeron, Christophe ^{[18
]}

Spreafico, Filippo ^{[16
]}

Graf, Norbert ^{[4
]}

机构：

[1] Princess Maxima Ctr Paediat Oncol, Dept Paediat Oncol, Lundlaan 6, NL-3584 EA Utrecht, Netherlands

[2] UCL, Great Ormond St Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England

[3] Netherlands Canc Inst, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands

[4] Saarland Univ, Dept Paediat Oncol & Haematol, Kirrberger Str 100, D-66421 Homburg, Germany

[5] La Timone Childrens Hosp, Dept Paediat Oncol & Haematol, 264 Rue St Pierre, F-13385 Marseille, France

[6] Cardiff Univ, Sch Med, Univ Hosp Wales, Dept Cellular Pathol, Heath Pk,Eastern Ave, Cardiff CF14 4XW, S Glam, Wales

[7] Univ Hosp Kiel, Dept Paediat Pathol, Kiel Paediat Tumour Registry, Christian Albrechts Pl 4, D-24118 Kiel, Germany

[8] Univ Hosp Saarland, Dept Radiotherapy, Kirrberger Str 100, D-66421 Homburg, Germany

[9] Acad Med Ctr Amsterdam, Dept Radiol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[10] Univ Med Ctr Utrecht, Dept Radiat Oncol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[11] Marciniak Hosp, Dept Paediat Surg, Fieldorfa 2, PL-54049 Wroclaw, Poland

[12] Med Univ, Dept Paediat Traumatol & Emergency Med, Wybrzeze Ludwika Pasteura 1, PL-50367 Wroclaw, Poland

[13] Hosp Univ Virgen del Rocio, Dept Paediat Oncol, Av Manuel Siurot S-N, Seville 41013, Spain

[14] Inst Nacl Canc INCA, Paediat Haematol Oncol Program, Praca Cruz Vermelha 23, BR-20230130 Rio De Janeiro, Brazil

[15] Univ Hosp Leuven, Dept Paediat Oncol, Herestr 49, B-3000 Leuven, Belgium

[16] Fdn IRCCS Ist Nazl Tumori, Dept Diagnost Pathol & Lab Med, Via Giacomo Venezian 1, I-20133 Milan, Italy

[17] Univ Wurzburg, Bioctr, Dev Biochem & Comprehens Canc Ctr Mainfranken, Josef Schneider Str 6, D-97080 Wurzburg, Germany

[18] Ctr Leon Berard, Inst Hematol & Oncol Pediat, 28 Prom, F-69008 Lyon, France

来源：

NATURE REVIEWS UROLOGY | 2017年 / 14卷 / 12期

关键词：

RANDOMIZED CONTROLLED-TRIAL; PREOPERATIVE CHEMOTHERAPY; STAGE-II; INTERNATIONAL-SOCIETY; PULMONARY METASTASES; FAVORABLE HISTOLOGY; INTERMEDIATE-RISK; INITIAL TREATMENT; ACTINOMYCIN-D; RENAL TUMORS;

D O I：

10.1038/nrurol.2017.163

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP-RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP-RTSG best available treatment standard.

引用

页码：743 / 752

页数：10

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