Comprehensive Assessment of Alcohol Consumption in People Living with HIV (PLWH): The New Orleans Alcohol Use in HIV Study

被引：21

作者：

Ferguson, Tekeda F. ^{[1
,2
]}

Theall, Katherine P. ^{[1
,3
]}

Brashear, Meghan ^{[1
,4
]}

Maffei, Vincent ^{[1
,5
]}

Beauchamp, Alaina ^{[2
]}

Siggins, Robert W. ^{[1
,4
]}

Simon, Liz ^{[1
,4
]}

Mercante, Donald ^{[1
,6
]}

Nelson, Steve ^{[1
,7
]}

Welsh, David A. ^{[1
,7
]}

Molina, Patricia E. ^{[1
,4
]}

机构：

[1] Louisiana State Univ, Comprehens Alcohol HIV AIDS Res Ctr, Hlth Sci Ctr, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Sch Publ Hlth, Hlth Sci Ctr, Epidemiol, New Orleans, LA 70112 USA

[3] Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA USA

[4] Louisiana State Univ, Hlth Sci Ctr, Sch Med, Physiol, New Orleans, LA 70112 USA

[5] Louisiana State Univ, Hlth Sci Ctr, Sch Med, Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA

[6] Louisiana State Univ, Hlth Sci Ctr, Sch Publ Hlth, Biostat, New Orleans, LA 70112 USA

[7] Louisiana State Univ, Hlth Sci Ctr, Sch Med, Pulmonol, New Orleans, LA 70112 USA

来源：

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH | 2020年 / 44卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Alcohol; HIV; Alcohol Use Disorders; Phosphatidylethanol; DISORDERS IDENTIFICATION TEST; PHOSPHATIDYLETHANOL FORMATION; SUBSTANCE USE; SELF-REPORT; TEST AUDIT; RAT-BRAIN; BIOMARKER; SAMPLE; VALIDITY; BLOOD;

D O I：

10.1111/acer.14336

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Background High frequency of alcohol use among people living with HIV (PLWH) warrants careful assessment and screening to better understand its impact on HIV disease progression and development of comorbidities. Due to the limitations of the tools used to measure alcohol use, the links to health consequences are not fully understood. Methods We completed a cross-sectional analysis to examine the prevalence of alcohol consumption using multiple alcohol assessment tools and their correlation and consistency in a cohort of PLWH (N = 365) enrolled in the New Orleans Alcohol Use in HIV (NOAH) Study. Alcohol use was assessed with the Alcohol Use Disorders Identification Test (AUDIT), timeline followback (TLFB) Calendar, lifetime drinking history, Alcohol and Drug Addiction Severity Index, and blood levels of phosphatidylethanol (PEth). Spearman's correlations were estimated for continuous measures of alcohol consumption; Wilcoxon rank-sum tests were used to compare means; and logistic regression was used to estimate odds of alcohol use by demographic characteristics. Results Self-report of current alcohol use varied from 58.9 to 73.7% depending on the assessment. All the self-reported alcohol measures showed statistically significant correlations with the biological marker PEth. The highest correlation was with TLFB grams (r = 0.67, p < 0.001). Using TLFB, 73.7% of the cohort reported using alcohol in the last 30 days, and 61.6% had a positive PEth value. The prevalence of risky drinkers, meeting the TLFB > 3 (women) or >4 (men) drinks/day or>7 (women) or>14 (men) drinks/week, was 49.0%. Medium-risk drinking defined as an AUDIT score >= 8 was reported in 40.3%, and high-risk drinkers/probable AUD (AUDIT score >= 16) was met by 17.0% of the cohort. Conclusions Our results demonstrate the importance of comprehensive assessments for alcohol use, including self-report via multiple assessment tools administered by trained staff, as well as the addition of biomarkers for improved classification of subjects into different drinking categories.

引用

页码：1261 / 1272

页数：12

共 63 条

[1] Cut-Point Levels of Phosphatidylethanol to Identify Alcohol Misuse in a Mixed Cohort Including Critically Ill Patients [J].