NEUROSCIENCE Channelopathies have many faces

被引:15
作者
Waxman, Stephen G. [1 ,2 ,3 ]
机构
[1] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Ctr Neurosci & Regenerat Res, New Haven, CT 06510 USA
[3] Vet Affairs Connecticut Healthcare Syst, West Haven, CT USA
关键词
SENSORY NEURONS; NA(V)1.7; PAIN; ERYTHROMELALGIA; MUTATIONS; GAIN; PN1;
D O I
10.1038/472173a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A sodium channel known for its role in the perception of pain also seems to be necessary for olfaction. The multiple roles of this channel and the diverse effects of its mutations raise intriguing questions. See Article p.186
引用
收藏
页码:173 / 174
页数:2
相关论文
共 13 条
[11]  
ToledoAral JJ, 1997, P NATL ACAD SCI USA, V94, P1527, DOI 10.1073/pnas.94.4.1527
[12]   Neurobiology - A channel sets the gain on pain [J].
Waxman, Stephen G. .
NATURE, 2006, 444 (7121) :831-832
[13]   Loss-of-function mutations in sodium channel Nav1.7 cause anosmia [J].
Weiss, Jan ;
Pyrski, Martina ;
Jacobi, Eric ;
Bufe, Bernd ;
Willnecker, Vivienne ;
Schick, Bernhard ;
Zizzari, Philippe ;
Gossage, Samuel J. ;
Greer, Charles A. ;
Leinders-Zufall, Trese ;
Woods, C. Geoffrey ;
Wood, John N. ;
Zufall, Frank .
NATURE, 2011, 472 (7342) :186-190