No evidence of Human papillomavirus DNA sequences in invasive breast carcinoma

被引：68

作者：

de Cremoux, Patricia ^{[1
]}

Thioux, Martine ^{[1
]}

Lebigot, Ingrid ^{[2
]}

Sigal-Zafrani, Brigitte ^{[1
]}

Salmon, Remy ^{[3
]}

Sastre-Garau, Xavier ^{[1
]}

机构：

[1] Inst Curie, Dept Tumor Biol, F-75248 Paris 05, France

[2] Inst Curie, Biol Resources Ctr, F-75248 Paris, France

[3] Inst Curie, Dept Surg, F-75248 Paris 05, France

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2008年 / 109卷 / 01期

关键词：

Human papillomavirus; DNA; breast carcinoma;

D O I：

10.1007/s10549-007-9626-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is one of the most frequently diagnosed cancers in women in France, but its aetiology remains unknown. Viruses including Epstein-Barr virus (EBV), a human equivalent of murine mammary tumour virus (MMTV) and human papillomavirus (HPV) have been detected in benign breast tissues and breast tumours and are considered to be involved in the aetiology of breast cancer. The aim of this study was to determine the prevalence of high-risk oncogenic HPVs in breast carcinoma from French patients. Fifty unselected DNA samples extracted from invasive breast carcinoma tissues were analysed. Polymerase chain reaction (PCR) was performed to amplify both consensus GP5 + /GP6 + HPV sequences and specific sequences for HPV types 16, 18, 33, 45 and 6-11. No HPV-DNA sequences were detected in our series of 50 samples. These data argue against the role of oncogenic HPV in the pathogenesis of breast cancer.

引用

页码：55 / 58

页数：4

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