Expression of angiopoietin-1 and the receptor Tie-2 mRNA in rat brains following intracerebral hemorrhage

被引：2
|
作者：
Zhou, HuaJun [1 ]
Tang, Tao [1 ,2 ]
Guo, Canjie [1 ]
Zhang, Hainan [1 ]
Zhong, JianHua [1 ]
Zheng, Jie [3 ]
Luo, JieKun [1 ]
Lin, Yuan [1 ]
Liu, Wei [1 ]
Luo, WenFang [1 ]
Yang, QiDong [2 ]
机构：
[1] Cent S Univ, Xiangya Hosp, Inst Integrat Med, Changsha, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp, Inst Neurol, Changsha, Hunan, Peoples R China
[3] Cent S Univ, Xiangya Hosp, Minist Hlth China, Key Lab Canc Prote, Changsha, Hunan, Peoples R China
来源：
ACTA NEUROBIOLOGIAE EXPERIMENTALIS | 2008年 / 68卷 / 02期
关键词：
intracerebral hemorrhage; angiopoietin-1; Tie-2; receptor; angiogenesis;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Angiopoietin-1 (Ang-1) belongs to a novel family of endothelial growth factors that function as ligands for an endothelial-specific receptor tyrosine kinase (Tie-2). The Ang-1/Tie-2 system may contribute to angiogenesis and vascular remodeling by mediating interactions of endothelial cells with smooth muscle cells and pericytes. The spatial distribution and temporal expression of Ang-1 and Tie-2 in the rat brain were studied following collagenase-induced intracerebral hemorrhage (ICH), by immunohistochemistry and reverse transcription-polymerase chain (RT-PCR) analysis, respectively. Immunohistochemical analysis revealed that some Ang-1 or Tie-2-positive dilated vessels resided around the hematoma and extended into the clot. RT-PCR analysis showed that Ang-1 and Tie-2 mRNA signal was detected at 2 days and persisted for 28 days after ICH. These findings suggest that ICH could lead to upregulation of Ang-1 and the receptor Tie-2 mRNA.
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页码：147 / 154
页数：8
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