Expression of angiopoietin-1 and the receptor Tie-2 mRNA in rat brains following intracerebral hemorrhage

被引：2
|
作者：
Zhou, HuaJun [1 ]
Tang, Tao [1 ,2 ]
Guo, Canjie [1 ]
Zhang, Hainan [1 ]
Zhong, JianHua [1 ]
Zheng, Jie [3 ]
Luo, JieKun [1 ]
Lin, Yuan [1 ]
Liu, Wei [1 ]
Luo, WenFang [1 ]
Yang, QiDong [2 ]
机构：
[1] Cent S Univ, Xiangya Hosp, Inst Integrat Med, Changsha, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp, Inst Neurol, Changsha, Hunan, Peoples R China
[3] Cent S Univ, Xiangya Hosp, Minist Hlth China, Key Lab Canc Prote, Changsha, Hunan, Peoples R China
来源：
ACTA NEUROBIOLOGIAE EXPERIMENTALIS | 2008年 / 68卷 / 02期
关键词：
intracerebral hemorrhage; angiopoietin-1; Tie-2; receptor; angiogenesis;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Angiopoietin-1 (Ang-1) belongs to a novel family of endothelial growth factors that function as ligands for an endothelial-specific receptor tyrosine kinase (Tie-2). The Ang-1/Tie-2 system may contribute to angiogenesis and vascular remodeling by mediating interactions of endothelial cells with smooth muscle cells and pericytes. The spatial distribution and temporal expression of Ang-1 and Tie-2 in the rat brain were studied following collagenase-induced intracerebral hemorrhage (ICH), by immunohistochemistry and reverse transcription-polymerase chain (RT-PCR) analysis, respectively. Immunohistochemical analysis revealed that some Ang-1 or Tie-2-positive dilated vessels resided around the hematoma and extended into the clot. RT-PCR analysis showed that Ang-1 and Tie-2 mRNA signal was detected at 2 days and persisted for 28 days after ICH. These findings suggest that ICH could lead to upregulation of Ang-1 and the receptor Tie-2 mRNA.
引用
收藏
页码：147 / 154
页数：8
相关论文
共 50 条
  • [1] Tie-2 and angiopoietin-1 expression in human thyroid tumors
    Mitsutake, N
    Namba, H
    Takahara, K
    Ishigaki, K
    Ishigaki, J
    Ayabe, H
    Yamashita, S
    THYROID, 2002, 12 (02) : 95 - 99
  • [2] Electrical stimulation upregulates angiopoietin-1/Tie-2 mRNA expression in a rat model of focal cerebral ischemia
    Li, Shasha
    Yang, Yonghong
    Gao, Qiang
    He, Jing
    He, Chengqi
    NEURAL REGENERATION RESEARCH, 2010, 5 (19) : 1470 - 1474
  • [3] Electrical stimulation upregulates angiopoietin-1/Tie-2 mRNA expression in a rat model of focal cerebral ischemia
    Shasha Li
    Neural Regeneration Research, 2010, 5 (19) : 1470 - 1474
  • [4] Clinical relevance of angiopoietin-1, angiopoietin-2, and their receptor Tie-2 expression in acute myeloid leukemia
    Safaa M. El Karaksy
    Nancy M. El Guindy
    Heba M. Gouda
    Mervat M. Khorshied
    Iman A. Shaheen
    Reham E. Abu Khalil
    Noha Y. Ibrahim
    Comparative Clinical Pathology, 2012, 21 (6) : 1171 - 1177
  • [5] Clinical relevance of angiopoietin-1, angiopoietin-2, and their receptor Tie-2 expression in acute myeloid leukemia
    El Karaksy S.M.
    El Guindy N.M.
    Gouda H.M.
    Khorshied M.M.
    Shaheen I.A.
    Khalil R.E.A.
    Ibrahim N.Y.
    Comparative Clinical Pathology, 2011, 20 (4) : 341 - 347
  • [6] Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring
    Staton, C. A.
    Valluru, M.
    Hoh, L.
    Reed, M. W. R.
    Brown, N. J.
    BRITISH JOURNAL OF DERMATOLOGY, 2010, 163 (05) : 920 - 927
  • [7] Expression of Angiopoietin-1, Angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation
    Yuan, HT
    Suri, C
    Yancopoulos, GD
    Woolf, AS
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1999, 10 (08): : 1722 - 1736
  • [8] Angiopoietin-1, angiopoietin-2 and Tie-2 expression in eutopic endometrium in advanced endometriosis
    Hur, Sung Eun
    Lee, Ji Young
    Moon, Hye-Sung
    Chung, Hye Won
    MOLECULAR HUMAN REPRODUCTION, 2006, 12 (07) : 421 - 426
  • [9] Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing
    Chun Yang Wen
    Masahiro Ito
    Long-Dian Chen
    Mutsumi Matsuu
    Kazuko Shichijo
    Toshiyuki Nakayama
    Masahiro Nakashima
    Zhao-Min Xu
    Akira Ohtsuru
    Chao-Tien Hsu
    Ichiro Sekine
    Journal of Gastroenterology, 2003, 38 : 431 - 435
  • [10] Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing
    Wen, CY
    Ito, M
    Chen, LD
    Matsuu, M
    Shichijo, K
    Nakayama, T
    Nakashima, M
    Xu, ZM
    Ohtsuru, A
    Hsu, CT
    Sekine, I
    JOURNAL OF GASTROENTEROLOGY, 2003, 38 (05) : 431 - 435
12345