The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity

被引：166

作者：

Ovsyannikova, Inna G. ^{[1
]}

Haralambieva, Iana H. ^{[1
]}

Crooke, Stephen N. ^{[1
]}

Poland, Gregory A. ^{[1
]}

Kennedy, Richard B. ^{[1
]}

机构：

[1] Mayo Clin, Vaccine Res Grp, Guggenheim Bldg 611C,200 First St SW, Rochester, MN 55905 USA

来源：

IMMUNOLOGICAL REVIEWS | 2020年 / 296卷 / 01期

关键词：

alleles; coronavirus; COVID-19; genes; genetic variation; genome-wide association study; GWAS; HLA; immunogenetics; polymorphisms; single nucleotide; SARS; SARS-CoV-2; severe acute respiratory syndrome; systems biology; vaccine; ACUTE-RESPIRATORY-SYNDROME; MANNOSE-BINDING LECTIN; MIGRATION INHIBITORY FACTOR; CLASS-II ALLELES; SYNDROME-CORONAVIRUS; DC-SIGN; FUNCTIONAL POLYMORPHISMS; CLINICAL CHARACTERISTICS; HONG-KONG; ASSOCIATION;

D O I：

10.1111/imr.12897

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus-mediated disease. The initial sections focus on seasonal coronaviruses, SARS-CoV, and MERS-CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS-CoV-2 and COVID-19. The article concludes by discussing research areas with current knowledge gaps and proposes several avenues for future scientific exploration in order to develop new insights into the immunology of SARS-CoV-2.

引用

页码：205 / 219

页数：15

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