Bacterial imbalance and gut pathologies: Association and contribution of E-coli in inflammatory bowel disease

被引：53

作者：

Khan, Shahanavaj ^{[1
,2
]}

Imran, Ahamad ^{[3
]}

Malik, Abdul ^{[4
]}

Chaudhary, Anis Ahmad ^{[5
]}

Rub, Abdur ^{[6
]}

Jan, Arif Tasleem ^{[7
]}

Syed, Jakeera Begum ^{[3
,8
]}

Rolfo, Christian ^{[9
,10
]}

机构：

[1] King Saud Univ, Dept Pharmaceut, Coll Pharm, Nanomed Res Unit, POB 2457, Riyadh 11451, Saudi Arabia

[2] SRGC, Dept Biosci, Muzaffarnagar, India

[3] King Saud Univ, King Abdullah Inst Nanotechnol, Riyadh, Saudi Arabia

[4] King Saud Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Riyadh, Saudi Arabia

[5] Al Imam Mohammad Ibn Saud Islamic Univ, Coll Med, Dept Pharmacol, Riyadh, Saudi Arabia

[6] Majmaah Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Majmaah, Saudi Arabia

[7] Yeungnam Univ, Sch Biotechnol, Gyongsan, South Korea

[8] Dar Al Uloom Univ, Coll Med & Dent, Riyadh, Saudi Arabia

[9] Antwerp Univ Hosp, Oncol Dept, Phase I Early Clin Trials Unit, Edegem, Belgium

[10] Antwerp Univ Hosp, MOCA, Edegem, Belgium

来源：

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES | 2019年 / 56卷 / 01期

关键词：

Bacteria; E; coli; etiology; dysbiosis; immune system; IBD; INVASIVE E. COLI; CROHNS-DISEASE; ILEAL MUCOSA; INTESTINAL MICROBIOTA; ANTIBIOTIC-THERAPY; PEDIATRIC-PATIENTS; HOST METABOLISM; TH17; CELLS; T-CELLS; GENE;

D O I：

10.1080/10408363.2018.1517144

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Hosts and microbes have co-evolved over millions of years. Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated diseases. Although the etiology of IBD remains an enigma, various studies have proposed the involvement of mucosa-associated Escherichia coli (E. coli) strains in the pathogenesis of IBD. E. coli, a usual inhabitant of the intestine, causes disease after acquiring virulence factors; however, the mechanisms underlying this phenomenon are not well understood. In the present review, we will discuss recent findings on how gut E. coli regulates and controls gut homeostasis and the pathogenesis of IBD. We will also summarize current knowledge regarding the cause, mechanism, genetics, and environmental factors involved in the regulation of IBD. Furthermore, we will discuss the possibility of alterations in innate and acquired immunity during the course of disease as well as possible treatment.

引用

页码：1 / 17

页数：17

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