Cu-Catalyzed Oxidative C(sp2)-H Cycloetherification of o-Arylphenols for the Preparation of Dibenzofurans

被引:121
作者
Zhao, Jiaji [1 ,2 ]
Wang, Yong [1 ,2 ]
He, Yimiao [1 ,2 ]
Liu, Lanying [1 ,2 ]
Zhu, Qiang [1 ,2 ]
机构
[1] Chinese Acad Sci, Guangzhou Inst Biomed, State Key Lab Resp Dis, 190 Kaiyuan Ave, Guangzhou 510530, Guangdong, Peoples R China
[2] Chinese Acad Sci, Guangzhou Inst Hlth, State Key Lab Resp Dis, Guangzhou 510530, Guangdong, Peoples R China
基金
美国国家科学基金会;
关键词
N BOND FORMATION; DIRECT ARYLATION; H FUNCTIONALIZATION; COUPLING REACTIONS; RING-CLOSURE; PALLADIUM; CARBAZOLES; CYCLIZATION; DERIVATIVES; ACTIVATION;
D O I
10.1021/ol203442a
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new process involving copper-catalyzed aerobic C(sp(2))-H activation, followed by cycloetherification, has been developed. This reaction serves as a direct method for the preparation of multisubstituted dibenzofurans starting with o-arylphenols. The presence of a strong para-electron-withdrawing group (e.g., NO2) on the phenol is essential for the success of the reaction.
引用
收藏
页码:1078 / 1081
页数:4
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